吉西他滨联合替吉奥一线治疗晚期胰腺癌疗效及安全性评价

Efficacy and Safety of Gemcitabine Combined with S-1 in the First-line Treatment of Advanced Pancreatic Cancer

目的研究吉西他滨联合替吉奥一线治疗晚期胰腺癌的临床疗效及安全性,为其能提高晚期胰腺癌患者生存率提供依据。方法选取2014年德阳市第二人民医院诊治的50例晚期胰腺癌患者为对照组,2015年在本院诊治的50例晚期胰腺癌患者为观察组。对照组采用吉西他滨治疗,观察组采用吉西他滨+替吉奥治疗;比较两组患者的临床疗效及治疗中表现的各种毒副作用。结果观察组患者治疗后的有效率为40.00%,疾病得到控制率为72.00%;对照组治疗的有效率为24.00%,控制率为44.00%。观察组总毒副作用发生率(58.00%)显著少于对照组(70.00%),差异有统计学意义(P<0.05)。结论吉西他滨联合替吉奥一线治疗晚期胰腺癌患者明显减少单一用药的毒副作用,减轻临床症状,疗效显著值得医师推广应用。

Objective To evaluate the clinical effect and safety of gemcitabine combined with S-1 in the first-line treatment of advanced pancreatic cancer therapy and combination therapy. It can provide a basis for improving the surviving fraction of advanced pancreatic cancer patients. Methods The investigation 50 cases of advanced pancreatic cancer patients in the second people’ s hospital in 2014 were treated as the control group. 50 cases of advanced pancreatic cancer patients were checked in 2015 in our hospital as the observation. Gemcitabine was used to treat the control group and combined treatment（ gemcitabine ＋ S-1） treated the observation. The research record and counted the data by comparing various toxic and side effect in the clinical effect of two groups with monotherapy and combined medication in the treatment. Results The effective rate was 40% and the control rate was 72. 00% with The observation group after treatment. The effective rate was 24. 00% and the control rate was 44. 00% with the control group. The total incidence rate of toxic and side effect of the observation group（ 58. 00%） significantly was less than t The total incidence rate of toxic and side effect of the control group（ 70. 00%）. The difference was statistically significant（ P 〈 0. 05）. Conclusion Gemcitabine combined with S-1 in the first-line treatment of patients with advanced pancreatic cancer significantly reduces the toxic and side effect of monotherapy,improves the surviving fraction of patients, reduces the clinical symptoms and the significant efficacy is worthy of popularization and application by doctors.