皮下注射硼替佐米治疗多发性骨髓瘤流程改良与实践

Improve of Process and Practice in Injection of Bortezomib to Treatment Multiple Myeloma

目的探索研究改良皮下注射硼替佐米治疗多发性骨髓瘤的临床效果。方法选取2016年1月—2017年2月徐州市中心医院血液科收治的90例多发性骨髓瘤病患者作为研究对象。将患者按照随机对照原则分为观察组和对照组,其中对照组患者45例采用常规注射方式给药,观察组患者采用改良皮下注射方式给药,建立《硼替佐米皮下注射登记本》记录注射部位的情况。观察患者给药后30min内疼痛程度以及给药后24h内患者注射部位毒副作用发生情况并进行对比。结果观察组注射后疼痛程度低于对照组,注射后毒副作用少于对照组(P<0.05)。结论采用改良后皮下注射方式能够降低多发性骨髓瘤患者注射硼替佐米后局部毒副作用,有效降低患者疼痛程度,降低患者痛苦,改良流程建立《硼替佐米皮下注射登记本》,节约了护士时间,提高了工作效率,值得在临床中推广应用。

Objective To explore the clinical effect of modified subcutaneous injection of bortezomib in the treatment of multiple myeloma. Methods 90 cases of multiple myeloma patients from January 2016 to February 2017 Department of Hematology of Xuzhou Center Hospitalas the research objection. The patients were randomly divided into observation group and control group,45 patients in the control group were treated with conventional injection administration,the observation group were treated by modified injection subcutaneously to establish registration record of the injection site of bortezomib. Patients were observed grade of pain in 30 min and adverse reactions of injection sites within 24 h to compared and evaluated. Results The grade of pain in the observation group was significantly lower than the control group（ P 〈 0. 05）. Conclusion The modified subcutaneous injection can significantly reduce pain in patients and local adverse reactions of bortezomib in multiple myeloma patients. Improve of process in establishment of registration record of the injection site of bortezomib save the time of nurses and improve work efficiency,it is worth in clinical application.