血清降钙素原在新生儿感染早期的诊断价值

Role of serum procalcitonin in early diagnosis of neonatal infection

目的:分析血清降钙素原(PCT)在新生儿感染早期诊断中的价值。方法:分别选择非感染患者和临床诊断的感染患者80例,将其作为非感染组和感染组,选择全自动免疫荧光分析仪,通过半定量固相免疫测定法对2组患者的血清PCT水平进行检测;另外选择全自动生化分析仪,通过免疫散射比浊法对2组患者的血清C-反应蛋白(CRP)水平进行检测。对2组患者的检测结果进行比较。结果:感染组患者的血清PCT水平、CRP水平显著性高于非感染组患者(P<0.05);通过ROC曲线分析可知,PCT的ROC曲线下面积和最佳临界值分别为0.879μg/L和0.51μg/L;CRP的ROC曲线下面积和最佳临界值分别为0.694μg/L和8.01μg/L。在阳性预测值和特异度方面,PCT显著低于CRP(P<0.05);在ROC曲线下面积、灵敏度以及阴性预测值方面,PCT显著高于CRP(P<0.05)。结论:血清降钙素原在新生儿感染的早期诊断中具有非常重要的价值。

Objective： To analyze the role of serum procalcitonin （ PCT ） in the early diagnosis of neonatalinfection Methods： 80 non-infected neonates and 80 infected neonates were enrolled as non-infection group respectively. The level of serumPCT was detected by semi-quantitative solid phase immunoassay, protein was detected by immune rate nephelometry（IRN）. The detection results were compared betweenThe serum PCT and CRP levels in the infection group were significantly higher than those in the non-infection group （ P 〈 0. 05 ）. ROCcurve analysis demonstrated ROC area under the PCT curve and the optimal critical value were 0. 879 μg/L and 0. 51 μg/L; the ROC area under the CRP curve and the optimal critical value were 0. 694 μg/Land 8. 01 μg/L. In terms predictive value and specificity, PCT was significantly lower than CRP（ P〈0.05 ）; in terms of ROC area under sensitivity and negative predictive value, PCT was significantly higher than CRP （P 〈0. 05）. Conclusion： Serum PCT is of greatvalue in the early diagnosis of neonatal infection.