凝血酶原复合物在围术期稀释性凝血障碍中的应用

Prothrombin complex concentrates treated for perioperative dilutional coagulopathy

目的:探讨凝血酶原复合物在围术期稀释性凝血障碍中的临床应用。方法:收集最新发表的相关文章,对凝血酶原复合物的药理特性、临床试验进行分析总结。结果:围术期稀释性凝血障碍是围术期出血的重要原因,是外科患者严重的并发症之一。凝血酶原复合物可迅速、高效补充凝血因子,改善患者凝血功能,减少出血。尽管其为血液制品,但病毒安全性可靠,且血栓风险低。结论:凝血酶原复合物治疗围术期稀释性凝血障碍安全有效。

Objective：To review the use of prothrombin complex concentrates in the treatment of perioperative dilutional coagulopathy.Methods：Analyze and summarize the latest researches related to the use of prothrombin complex concentrates in the treatment of perioperative dilutional coagulopathy.Results：Perioperative dilutional coagulopathy was the important cause of perioperative bleeding.Prothrombin complex concentrates could supplement coagulation factors quickly and efficiently,improve coagulation function and reduce bleeding.It showed viral and thrombogenic safety although being a blood product.Conclusion：Several clinical researches suggest that prothrombin complex concentrates may be a good perioperative hemostatic agent.