1例美洛西林/舒巴坦致儿童重型渗出性多形红斑文献复习

The literature review of a case of mezlocillin/sulbactam induced Stevens-Johnson syndrome

目的:探讨美洛西林/舒巴坦所致药品不良反应的一般规律和临床特点,为临床合理用药提供参考。方法:报道美洛西林/舒巴坦致重型渗出性多形性红斑1例,并检索2006—2016年间国内外医药期刊公开报道的美洛西林/舒巴坦致不良反应的病例,进行统计分析。结果:个案报道检索到12例,因过敏性休克死亡1例。美洛西林/舒巴坦致不良反应发生率低,其不良反应以过敏性皮肤瘙痒为主。结论:临床应高度重视美洛西林舒巴坦引起渗出性多形性红斑的不良反应,加强临床观察,确保用药安全。

Objective：To discuss the general principles and clinical characteristics of adverse drug reactions（ADRs） induced by mezlocillin/sulbactam in order to provide references for rational use of mezlocillin/sulbactam.Methods：One patient with Stevens-Johnson syndrome induced by mezlocillin/sulbactam was reported.Literature of mezlocillin/sulbactam-induced ADRs in domestic and oversea pharmaceutical journals from 2006 to 2016 were retrieved and analyzed.Results：Only 12 case reports were found among which one patient died of allergic shock.Mezlocillin/Sulbactam rarely caused ADRs,most of which were allergic skin pruritus.Conclusion：More attention should be paid to the Stevens-Johnson syndrome induced by mezlocillin/sulbactam to ensure its safe use.