高效液相色谱法测定人血浆中布比卡因浓度及其药代动力学

Bupivacaine plasma concentration in man measured by HPLC and its pharmacokinetics

本研究采用高效液相色谱法测定了11例施硬膜外麻醉的手术病人的血浆布比卡因浓度,将测定结果用微机处理,求出药动学参数。结果为:达峰时间0.57±0.21h,峰浓度0.86±0.23μg/ml,消除半衰期3.75±3.09h,消除速率常数0.3121±0.2134h^(-1),吸收半衰期0.15±0.08h,吸收速率常数6.22±3.65h^(-1),表观分布容积112±94.0L,清除率24.30±12.0L/h。

The concentration of bupivacaine in plasma wasmeasured by HPLC in 11 patients operated on underepidural aneathesia. The pharmacokinetic parametersare obtained by computerization. The data on peaktime, peak concentration, half life of elimination,constant elimination rate, half life of absorption, con-stand absorption rate, volumes of distribution andclearance are 0.57±0.21h, 0.86±0.23μg/ml,3.75±3.09h, 0.3121±0.32134h^(-1), 0.15±0.08h, 6.22±3.65h^(-1), 112±94L, 24.3±12.0L/h, respectively.