3种麻醉方法在小鼠骨科研究中的效果比较

Effect of Three Types of Anesthetic Methods in Mice Orthopedic Research

目的:比较三种麻醉方法对C57BL/6小鼠的麻醉效果,分析不同方法在骨科研究中的应用价值。方法:将45只C57BL/6小鼠随机分为A组(复方氯胺酮组)、B组(戊巴比妥钠组)、C组(舒泰联合多咪静组),比较3组的麻醉制动时间、诱导期、麻醉期、苏醒期以及麻醉深度和死亡率。结果:A组和C组麻醉期较短,C组较A组诱导期短,麻醉效果好,死亡率为0,安全可靠,但苏醒期较长;B组诱导期及麻醉期均较长,麻醉效果一般,死亡率最高。结论:C组可作为操作时间较短的骨科手术的最佳麻醉方案,B组可作为操作时间较长的骨科手术的麻醉选择。

The effect of three types of anesthetic methods were study to analyze the application value of these methods in orthopedic research. 45 C57 BL/6 mice were randomly divided into three groups,group A was given with ketamin,group B was injection with pentobarbital sodium and group C was administrated by Zoletil combined with Dexdomitor. The immobilization time,induction time,anesthesia time,recovery time,anesthetic depth and mortality rates were compared after the anesthetic agents were administered. The anesthesia times of group A and group C were shorter,and compared with group A,the induction time of group C was significantly reduced,furthermore,group C had a better anesthetic effect,a mortality rate of 0,which was safe and reliable,but the recovery time of group C was long. In group B,the induction time and the duration of anesthesia time were obviously increased,with general anesthesia effect and highest mortality rate. Group C can be used as the best anesthesia program for orthopedic surgery witch operation time was shorter,and when the operation time was longer,group B can be used as a choice.