不同状态的乙肝病毒感染者血清Tim-3水平与疾病进展关系研究

Study on the relationship between serum Tim-3 level and the disease process in different state of hepatitis B virus

目的对不同状态的HBV感染者血清Tim-3水平变化与疾病进程关系的初步探讨。方法检测39例慢性乙肝患者(CHB组)、42例乙肝病毒携带者(AsC组)、31例慢性乙肝急性发作患者及40例健康体检者血清Tim-3水平,并同时检测血清ALT、TBIL、HBV-DNA、HBc-Ab水平,并做统计学处理。结果慢性HBV感染者血清Tim-3水平较健康组升高,急性发作组Tim-3、ALT、HBcAb水平显著高于CHB组及AsC组,Tim-3水平与ALT、HBcAb成正相关。相关性分析显示当2×ULN<ALT<10×ULN(正常范围上限)与Tim-3相关性更加明显,差异有统计学意义(P<0.01);所有患者Tim-3水平与HBV-DNA载量无明显相关。结论慢性HBV感染者有较高的Tim-3水平,且急性发作时Tim-3升高更明显,与ALT明显相关,可以作为慢性HBV感染者病情变化的监测指标之一。

Objective Analysis the change of serum Tim-3 level in different state of chronic hepatitis B virus infected patients and the relationship with the disease process. Methods Detect serum Tim-3 levels in 39 cases of chronic hepatitis B patients（CHB）,42 cases of hepatitis B virus carriers（AsC）,31 cases of chronic hepatitis B patients with acute exacerbation and 40 cases of healthy people, meanwhile detect the levels of serum ALT, TBIL, HBV-DNA and HBc- Ab,then make statistics processing. Results The levels of serum Tim-3 were higher in HBV infected patients than healthy group, the level of serum Tim-3,ALT, HBcAb in acute exacerbation group were significantly higher than that of CHB and AsC group. There was positive correlation between Tim-3 and ALT, HBcAb . Correlation analysis showed that when the ALT levels between 2 ULN and 10 ULN（the limit of the normal range）,the correlation was more obvious,the difference was statistically significant （P〈0. 05）. There was no significant association between Tim-3 and HBV-DNA in all the patients. Conclusion Chronic HBV infected patients have a higher level of Tim-3,and more obvious when it acute exacerbation,and was significantly related with ALT level. It can be used as one of a monitoring indicator in the chronic HBV infected patients disease progression.