脐血干细胞肝动脉移植治疗慢性肝衰竭的临床研究

A Clinical Research on Treating Chronic Hepatic Failure with Transplantation of Umbilical Cord Blood Stem Cells into Hepatic Artery

目的:观察脐血干细胞肝动脉移植治疗慢性肝功能衰竭的临床疗效。方法:40例乙肝慢性肝功能衰竭患者,随机分成治疗组20例,对照组20例,治疗组20例在内科综合治疗的基础上给予脐血干细胞肝动脉移植,每个病人干细胞的回输量均在(2~5)×107/L。对照组20例给予常规内科综合治疗。分别观察治疗前后两组患者一般情况、生化指标的变化。结果:经脐血干细胞肝动脉移植后4~12周患者一般情况明显好转,肝脏合成、代谢、再生等相关指标逐步改善,差异有统计学意义(P<0.05)。结论:通过脐血干细胞肝动脉移植治疗慢性肝功能衰竭患者,在近期内可明显改善临床症状及相关生化指标。

Objective： To observe the clinical effects of treating chronic hepatic failure with transplantation of umbilical cord blood stem cells into hepatic artery. Methods： 40 cases of chronic hepatitis B patients with liver failure were randomly divided into a treatment group and a control group evenly. The patients in the control group were given the routine medical therapy,while the patient in the treatment group were given transplantation of umbilical cord blood stem cells into hepatic artery additionally,with（ 2 - 5） ×10^7/L of reinfusion of stem cells for each patient. Gernal conditions and the changes of biochemical indexes before and after the treatment in both groups were observed respectively. Results： The general conditions of the patients were remarkably improved after 4-12 weeks＇ s transplantation of umbilical cord blood stem cell,and the relevant indicators such as liver synthesis,metabolism and regeneration were improved gradually as well. The differences were statistical significant（ P〈0.05）. Conclusion： The clinical symptoms and relevant biochemical indexes of the patients with chronic hepatic failure can be improved markedly within the short-term after being treated with transplantation of umbilical cord blood stem cells into hepatic artery.