阿仑膦酸钠、鲑鱼降钙素联合钙尔奇D治疗老年骨质疏松症的疗效观察

Allen phosphonic acid sodium,calcium salmon calcitonin and he D combination treatment the curative effect of senile osteoporosis

目的观察阿仑膦酸钠、鲑鱼降钙素联合钙尔奇D治疗老年骨质疏松症的临床疗效。方法选取医院2012年3月-2014年10月收治的老年骨质疏松症患者200例,按照入院治疗的顺序随机分为试验组与对照组,每组100例。对照组给予钙尔奇D治疗,试验组在对照组治疗的基础上给予阿仑膦酸钠与鲑鱼降钙素治疗,比较2组患者的治疗效果。结果试验组总有效率为92.0%高于对照组的62.0%,差异有统计学意义(P<0.05)。治疗前2组患者的血清骨钙素(BGP)、抗酒石酸酸性磷酸酶(TRACP)、腰椎骨密度(BMD)、股骨颈BMD值比较差异均无统计学意义(P>0.05);治疗后试验组BGP、TRACP、腰椎BMD均改善,且试验组明显优于对照组,差异均有统计学意义(P<0.05)。结论阿仑膦酸钠、鲑鱼降钙素联合钙尔奇D治疗老年骨质疏松症临床疗效显著,可明显改善患者不良症状,提高患者的日常生活质量,值得大力推广与应用。

Objective To explore the Allen phosphonic acid sodium,calcium salmon calcitonin and he D combination treatment the clinical curative effect of senile osteoporosis. Methods 200 cases of patients with senile osteoporosis were selected,which were treated in hospital from March 2012 to October 2014,they were randomly divided into experimental group and control group,each group of 100 cases. The control group was treated with Calcium D,on the basis of the control group,the experimental group was treated with alendronate and salmon calcitonin,the treatment effect of two groups were compared. Results The total effective rate of the experimental group（ 92. 0%） was higher than that of the control group（ 62. 0%）,the difference was statistically significant（ P 〈 0. 05）. There were no significant differences in serum BGP,tartaric acid phosphatase（ TRACP）,lumbar vertebrae BMD（ BMD） and femoral neck BMD between the two groups before treatment（ P 〈 0. 05）; After treatment,the levels of BGP,TRACP and BMD were improved,and the experimental group was superior to the control group,the difference was statistically significant（ P 〈 0. 05）. Conclusion Alendronate sodium,salmon calcitonin combined with calcium Erqi D treatment of osteoporosis in elderly patients with significant clinical efficacy,it can significantly improve the patient＇s adverse symptoms,improve the quality of daily life of patients,It is worth promoting and application.