基于潜在类别分析探讨北京地区卵巢储备功能减退的中医证候分布规律

Distribution rules of TCM Syndromes of decline in ovarian reserve in Beijing based on potential category analysis

目的探讨北京地区卵巢储备功能减退(DOR)患者的证候学分布规律。方法以北京地区160例DOR患者为研究对像,结合文献回顾性调查、前瞻性横断面调査两种调查方式,运用SAS软件的Proc LCA模块,借助潜变量类别分析技术,探索建立卵巢储备功能减退中医证候潜类别模型,对患者中医证候分布规律进行研究。结果 160例DOR患者的中医证候分布为肝郁肾虚证117例(73.1%)、肾阳虚证35例(21.9%)、肝肾阴虚证8例(5%)。结论 DOR中医证候的潜类别变量模型均与肾的关系密切,符合临床证候表现。

Objective To discuss the syndrome distribution rules in patients with decline in ovarian reserve（DOR） in Beijing.Methods 160 DOR patients in Beijing were included as the subjects,and through literature retrospective survey and prospective cross-sectional survey,Proc LCA module of SAS software was used with the help of latent class analysis technology to explore the establishment of the latent class model of TCM syndromes of DOR and study the rules.Results TCM syndromes of DOR in160 cases were divided into 3 categories,respectively liver depression and kidney deficiency syndrome in 117 cases（73.1%）,kidney yang deficiency syndrome in 35 cases（21.9%）,and yin deficiency of liver and kidney syndrome in 8 cases（5%）.Conclusion The latent class variable model of TCM syndrome of DOR is closely related to the kidney,which complies with the clinical syndromes.