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《中国多发性骨髓瘤诊治指南(2017年修订)》疗效标准部分的解读 被引量:16

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摘要 在过去的十几年中,随着新药的应用,尤其在联合自体造血干细胞移植、移植后巩固治疗以及长期维持治疗后,多发性骨髓瘤( MM )患者的缓解率和缓解深度得到很大的改善. 超过50%的患者可以达到完全缓解(CR). 但令人不尽满意的是,尽管达到这样深层次的缓解,大部分患者终将复发,因此CR不能理想地反映深层次的缓解,需要新的疗效标准来定义比CR更深层次的疗效.
作者 刘俊茹 李娟
出处 《中华内科杂志》 CAS CSCD 北大核心 2017年第11期800-803,共4页 Chinese Journal of Internal Medicine
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  • 1Blad6 J, Samson D, Reeee D, et al. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Br J Haematol, 1998, 102: 1115-1123.
  • 2Durie BG, Harousseau JL, Miguel JS, et al. International uniformresponse criteria for multiple myeloma. Leukemia, 2006, 20: 1467-1473.
  • 3Zent CS, Wilson CS, Tricot G, et al. Oligoclonal protein bands and Ig isotype switching in multiple myeloma treated with high- dose therapy and hematopoietic cell transplantation. Blood, 1998, 91 3518-3523.
  • 4武永吉.多发性骨髓瘤//张之南,沈悌.血液病诊断及疗效标准.3版.北京:科学出版社,2007:232-235.
  • 5Wadhera RK, Kyle RA, Larson DR, et al. Incidence, clinical course, and prognosis of secondary monoclonal gammopathy of un- determined significance in patients with multiple myeloma. Blood, 2011, 118: 2985-2987.
  • 6Hovenga S, de Wolf JT, Guikema JE, et al. Autologons stem cell transplantation in multiple myeloma after VAD and EDAP courses: a high incidence of oligoclonal serum Igs post transplantation. Bone Marrow Transplant, 2000, 25: 723-728.
  • 7Niesvizky R, Jayabalan DS, [ clarithromycin ]/Revlimid Christos PJ, et al. BiRD (Biaxin [ lenalidomide ]/dexamethasone ) combination therapy results in sponse rates in treatment-naive Blood, 2008, 111:1101-1109. high complete- and overall-re- symptomatic multiple myeloma.
  • 8Mark T, Jayabalan D, Coleman M, et al Atypical serum immu- nofixation patterns frequently emerge in immunomodulatory thera- py and are associated with a high degree of response in multiple myeloma. Br J Haematol, 2008,143:654-660.
  • 9Gerritsen E J, Van To! M J, Van' t Veer MB, et al. Clonal dysregulation of the antibody response to tetanus-toxoid after bone marrow transplantation. Blood, 1994, 84 : 4374-4352.
  • 10Xiang Z, Cutler A J, Brownlie R J, et al. FcgammaRIIb controls bone marrow plasma cell persistence and apoptosis. Nat Immu- no1, 2007, 8 : 419-429.

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