血浆EB病毒DNA在弥漫大B细胞淋巴瘤中的预后意义

The prognostic significance of plasma Epstein-Barr virus DNA in patients with diffuse large B cell lymphoma

回顾性分析122例弥漫大B细胞淋巴瘤（DLBCL）临床资料,探讨血浆EB病毒（EBV）DNA阳性（≥1.0＆#215;103 copies/ml）与DLBCL预后的关系.结果显示,血浆EBV DNA阳性与Ann Arbor分期高（P=0.030）、有B症状（P=0.004）、LDH水平高（P=0.001）相关.单因素分析显示,血浆EBV DNA阳性是影响DLBCL患者总体生存（HR=0.223,95%CI 0.096-0.518,P〈0.001）及无进展生存（HR=4.417,95%CI 1.911-10.208,P〈0.001）的预后因素;多因素分析显示,血浆EBV DNA可能是DLBCL总体生存的独立预后因素（HR=0.409,95%CI 0.166-1.008,P=0.052）.

To retrospectively analyze the prognostic significance of plasma Epstein -Barr virus （EBV） DNA in 122 patients with diffuse large B cell lymphoma （DLBCL）.Plasma EBV DNA positivity was related to advanced disease stage （ P =0.030 ） , B symptoms （ P =0.004 ） and elevated serum lactic dehydrogenase （LDH） （P=0.001）.Furthermore, univariate analysis indicated that plasma EBV DNA level was associated with worse overall survival （OS） （HR=0.223, 95%CI 0.096-0.518, P〈0.001） and worse progression free survival （PFS） （HR =4.417, 95%CI 1.911 -10.208, P 〈0.001）, whereas multivariate analysis showed plasma EBV DNA as a probable independent prognostic factor of clinical outcome（HR=0.409, 95%CI 0.166-1.008, P=0.052）.