双歧三联活菌胶囊辅助治疗2型糖尿病疗效及对血清炎症因子的影响

Effect of Bifid Triple Viable Capsules Adjuvant Tharapy and Influence on Inflammation Cytokine in Type 2 Diabetes Mellitus

目的:探讨双歧三联活菌胶囊辅助治疗2型糖尿病(T2DM)的疗效和对患者血清炎症因子水平的影响。方法:102例T2DM患者按入院单双号分为观察组(n=53)和对照组(n=49)。对照组予二甲双胍片0.5 g,po,tid;观察组在对照组基础上加用双歧三联活菌胶囊0.42 g,po,tid。8周为一疗程。治疗前后检测两组患者果糖胺、糖化血红蛋白和空腹血糖,血清TNF-α、脂联素的水平变化,并记录不良反应。结果:治疗后,两组患者果糖胺、糖化血红蛋白、空腹血糖、TNF-α水平均较治疗前下降,脂联素则较治疗前显著增高(P<0.05);且与对照组相比,对照组改善更为明显(P<0.05)。两组均未见药品不良反应发生。结论:补充益生菌有助于T2DM患者血糖的控制,推测与降低炎症反应有关。

Objective：To investigate the clinical effect of probiotics adjuvant therapy and influence on inflammation in the patients with type 2 diabetes mellitus （T2DM）. Methods：Totally 102 patients with T2DM were divided into probiotics group （n=53） and the control group （n=49）according to the odd-even admission number. The control group received metformin tablets of 0. 5g,po,tid,pro-bioties group received bifid triple viable capsules of 0. 42g,po,tid additionally, and the treatment course was 8 weeks. Before and after the treatment, the levels of fructosamine（FMN）, fasting bloodglucose（FBG）,HbA1c,and the serum levels of TNF-αand adiponectin were determined, and the adverse reactions were recorded. Results：After the treatment, the levels of FMN, FBG, HbA1c and TNF-αof the two groups were significantly decreased than before, and adiponectin was significantly increased than before （P〈0. 05）; com-pared with those of the control group, the indicators mentioned above were improved more greatly in probiotic group （P〈0. 05）. There were no obvious adverse reactions appeared in both groups. Conclusion：Probiotics is beneficial to glycemic control, and the mecha-nism is related to reducing inflammation.