粘着斑激酶在神经系统疾病中的作用研究进展

Research Progress in Focal Adhesion Kinase Used for Neurological Diseases

粘着斑激酶(focal adhesion kinase,FAK)是对动态调节细胞黏附结构至关重要的一种新型的非受体型蛋白酪氨酸激酶(non-receptor protein tyrosine kinase),通过与整合素(integrin)配体的结合实现酪氨酸位点的磷酸化而激活。有研究显示,FAK与神经系统发育、突触可塑性、神经系统疾病的发生发展密切相关。本文就近年来FAK在神经系统疾病中的作用作一综述。

Focal adhesion kinase （ FAK） is one of novel non-receptor protein tyrosine kinases critical for the dynamic regulation of cell adhesion structures,which is activated through the phosphorylation of its tyrosine residue by ligands that bind to integrins. Some studies have demonstrated that FAK has close relationship with nervous system development, synaptic plasticity and the occurrence and development of nervous system diseases. The review summarized the functions of FAK in neurological diseases.