探析阿仑膦酸钠对甲亢并骨质疏松症患者的临床治疗效果

The Study on the Clinical Effect of Alendronate Sodium on Hyperthyroidism and Osteoporosis

目的:研究阿仑膦酸钠对甲亢并骨质疏松症患者的临床治疗效果。方法:以2015年5月~2016年1月甲亢并骨质疏松症患者84例随机分两组,常规治疗组采用常规甲亢药物治疗,阿仑膦酸钠组在常规治疗组基础上给予阿仑膦酸钠治疗。比较两组患者甲亢并骨质疏松症治疗总有效率、不良反应发生率;治疗前和治疗后患者甲状腺功能指标和骨密度指标的差异。结果:阿仑膦酸钠组患者甲亢并骨质疏松症治疗总有效率高于常规治疗组,P<0.05;两组治疗前后血尿常规、肝肾功能、心电图、血糖血脂等情况无显著差异,仅各有1例出现便秘和腹痛,P>0.05;治疗前两组甲状腺功能指标和骨密度指标比较无显著差异,P>0.05;治疗后阿仑膦酸钠组甲状腺功能指标和骨密度指标改善幅度更大,P<0.05。结论:阿仑膦酸钠对甲亢并骨质疏松症患者的临床治疗效果确切,可有效改善患者甲状腺功能,提高骨密度,且无严重并发症,效果确切,值得推广。

Objective： To study the clinical effect of alendronate sodium on hyperthyroidism and osteoporosis. Methods. From May 2015 to January 2016, 84 patients with hyperthyroidism and osteoporosis were randomly divided into two groups, routine treatment group using conventional hyperthyroid drug treatment, alendronate sodium group given another treatment of alendronate sodium. Then we compared two groups with hyperthyroidism and osteoporosis treatment of total effective rate, adverse reaction rate, thyroid function and bone mineral density differences before and after the treatment. Results. The total effective rate of hyperthyroidism and osteoporosis was higher than that of conventional treatment group （P 〈0.05）. There was no significant difference in hematuria, liver and kidney function, electrocardiogram, blood glucose and blood lipid between the two groups before and after treatment. There were no significant differences in thyroid function index,and bone mineral density between the two groups before treatment （P 〉0.05）. After treatment, the levels of thyroid function and bone mineral density in alendronate group were significantly higher than those in the control group Greater, P〈0.05. Conclusion： The clinical effect of alendronate sodium on hyperthyroidism and osteoporosis is effective, which can improve the thyroid function and improve the bone density, and there is no serious complication. The effect is accurate and worthy of promotion.