前列地尔对高脂血症性急性胰腺炎患者的治疗效果及预后

Efficacy and prognosis of alprostadil in the treatment of patients with hyperlipidemia acute pancreatitis

目的研究前列地尔治疗高脂血症性急性胰腺炎(AP)患者的临床疗效和预后。方法选取2015年2月至2016年10月武警总医院收治的高脂血症性AP患者80例,根据随机数表法分为观察组及对照组各40例。所有患者入院后均给予常规治疗,对照组患者在此基础上给予奥曲肽治疗,观察组则常规治疗基础上给予前列地尔治疗。比较两组临床疗效、胃肠功能恢复时间、腹痛消失时间、住院时间以及血淀粉酶(AMP)、甘油三酯(TG)、及C-反应蛋白(CRP)水平变化情况。结果观察组轻、中度患者治疗总有效率为91.67%(22/24),显著高于对照组的64.00%(16/25),差异有统计学意义(P<0.05)。观察组患者的胃肠功能恢复时间、腹痛消失时间及住院时间分别为(3.8±0.2)d、(5.2±1.7)d、(9.2±2.1)d,均明显短于对照组的(5.0±1.3)d、(7.5±1.9)d、(11.8±2.3)d,差异均有统计学意义(P<0.05);治疗7 d后观察组患者的AMP、TG及CRP水平分别为(421.3±97.2)U/L、(4.3±2.3)mmol/L、(6.3±2.2)mg/L,均明显低于对照组的(475.8±103.5)U/L、(10.2±2.9)mmol/L、(12.7±2.4)mg/L,差异均有统计学意义(P<0.05)。结论在常规治疗基础上加用前列地尔治疗高脂血症性AP的临床疗效显著,值得推广应用。

Objective To study the efficacy and prognosis of alprostadil in the treatment of patients with hyper-lipidemic acute pancreatitis （AP）. Methods A total of 80 patients with hyperlipidemia AP, who admitted to our hospital from February 2015 to October 2016, were selected and divided into the observation group and the control group ac-cording to the random number table method, with 40 cases in each group. All the patients were given conventional treat-ment after admission. The control group was treated additionally with the octreotide therapy, and the observation group was given additionally alprostadil therapy. The clinical curative effect, gastrointestinal function recovery time, abdomi-nal pain disappear time, hospital stay time and the level changes of blood amylase （AMP）, fasting triglyceride （TG） and C-reactive protein （CRP） in the two groups were compared. Results The total effective rate of the mild and moderate patients in the observation group was 91.67%（22/24）, which was significantly higher than 64.00%（16/25） of the con-trol group （P〈0.05）. The recovery time of gastrointestinal function, abdominal pain disappeared time and hospitaliza-tion time of the observation group were respectively （3.8±0.2） d, （5.2±1.7） d, （9.2±2.1） d, which were significantly less than （5.0±1.3） d, （7.5±1.9） d, （11.8±2.3） d of the control group （P〈0.05）. After the treatment of 7 d, the levels of AMP, TG and CRP in the observation group were respectively （421.3 ± 97.2） U/L, （4.3 ± 2.3） mmol/L, （6.3 ± 2.2） mg/L, which were significantly lower than （475.8 ± 103.5） U/L, （10.2 ± 2.9） mmol/L, （12.7 ± 2.4） mg/L in the control group （all P〈0.05）. Conclusion Based on the conventional treatment, additional alprostadil has the remarkable consequence in the treatment of hyperlipidemic AP, which is worthy of popularization and application.