复发性口腔溃疡患者免疫指标及血清TNF-α、IL-2水平的变化

Changes of immune index and serum TNF-α,IL-2 in patients with recurrent oral ulcer

目的探讨复发性口腔溃疡(ROU)患者血清免疫球蛋白、补体及肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)水平的变化。方法选择2013年5月至2017年1月期间南平市人民医院口腔科诊治的80例ROU患者纳入观察组,并选择同期80例健康体检者纳入对照组,比较两组受检者血清Ig A、Ig M、Ig G、C3、C4及TNF-α、IL-2水平。结果两组受检者免疫球蛋白Ig A、Ig M、Ig G水平比较差异均无统计学意义(P>0.05);观察组患者的血清补体C3、C4分别为(0.78±0.21)g/L、(0.18±0.05)g/L,明显低于对照组的(1.65±0.58)g/L、(0.35±0.11)g/L,差异均有统计学意义(P<0.05);观察组患者血清TNF-α、IL-2水平分别为(14.58±2.73)pg/m L、(35.84±4.84)pg/m L,均明显高于对照组的(10.16±2.55)pg/m L、(21.87±4.16)pg/m L,差异均统计学意义(P<0.05)。结论复发性口腔溃疡的发病与体液免疫功能紊乱及其引起的炎症反应有关,通过测定患者血清免疫球蛋白及TNF-α、IL-2水平有利于患者预后的判断。

Objective To investigate the changes of serum immunoglobulin, complement and serum tumor ne-crosis factor alpha （TNF-α） and interleukin-2 （IL-2） in patients with recurrent oral ulcer. Methods A total of 80 cases of patients with recurrent oral ulcer, who admitted to Department of Stomatology of Nanping People＆#39;s Hospital from May 2013 to January 2017, were selected as the observation group, and 80 cases of healthy people were included into the con-trol group. The serum IgA, IgM, IgG, C3, C4 and TNF-α, IL-2 were compared between the two groups. Results There was no statistical difference between the two groups in serum IgA, IgM, IgG （P〉0.05）. The serum C3, C4 in the observa-tion group were （0.78±0.21） g/L, （0.18±0.05） g/L, respectively, which were significantly lower than （1.65±0.58） g/L and （0.35±0.11） g/L in the control group （P〈0.05）. The serum levels of TNF-α, IL-2 in the observation group were （14.58± 2.73） pg/mL, （35.84 ± 4.84） pg/mL, respectively, which were significantly higher than （10.16 ± 2.55） pg/mL and （21.87 ± 4.16） pg/mL in the control group （P〈0.05）. Conclusion The occur of recurrent oral ulcer associated with the distur-bance of humoral immunity and inflammatory response, and the determination of serum TNF-α, IL-2 is conducive to the prognosis judgment.