T2DM患者血浆Gas6、Omentin-1与IR、肥胖及脂代谢的相关性分析

Correlations of serum Gas6 and Omentin-1 with insulin resistance and lipid metabolism in type 2 diabetes patients

目的探讨2型糖尿病(T2DM)患者血浆生长停滞特异性蛋白(Gas6)和网膜素-1(Omentin-1)与胰岛素抵抗(IR)、肥胖及脂代谢的相关性。方法选择超重肥胖T2DM患者[体重指数(BMI)≥25 kg/m2]40例,体重正常T2DM患者50例,健康体检者30例,应用酶联免疫吸附法测定3组血浆Gas6、Omentin-1水平,同时检测空腹胰岛素、空腹血糖及血脂,比较之间相关性。结果 T2DM患者血浆Gas6、Omentin-1水平降低,超重肥胖组低于体重正常组和对照组(P<0.05)。Gas6和Omentin-1水平与稳态模型胰岛素抵抗指数、BMI、甘油三脂、胆固醇及低密度脂蛋白胆固醇呈负相关(P<0.05),与高密度脂蛋白胆固醇、胰岛素分泌指数呈正相关(P<0.05)。结论 T2DM患者的血浆Gas6、Omentin-1水平变化与IR、肥胖及脂代谢相关,可作为T2DM预测指标。

Objective To investigate plasma growth arrest-specifc 6 （Gas6） and Omentin-1 levels of type 2 diabetes patients and to explore the relationships of plasma Gas6 and Omentin-1 levels with insulin resistance （IR）, obesity and lipid metabolism. Methods The fasting plasma levels of Omentin-1 and Gas6 were detected by enzyme-linked immunosorbent assay （ELISA） in 40 T2DM patients with overweight obesity （BMI ≥ 25 kg/m2）, 50 T2DM patients with normal weight and 30 normal controls. Meanwhile, data including fasting insulin （Fins）, blood glucose and blood lipids were also obtained. The correlations of plasma Gas6 and Omentin-1 levels with those indicators were analyzed. Results Compared with the normal control group, the plasma levels of Gas6 and Omentin-1 were lower in the type 2 diabetes patients （P 〈 0.05）. The plasma Gas6 and Omentin-1 levels of the overweight obesity group were signifcantly lower than those in the normal weight group and the normal control group （P 〈 0.05）. The serum Gas6 and Omentin-1 levels were positively correlated with HDL-C （P 〈 0.05）, but negatively correlated with HOMA-IR,BMI, TG, TC and LDL-C （P 〈 0.05）. Conclusions The levels of plasma Gas6 and Omentin-1 are associated with insulin resistance, obesity and lipid metabolism, which may contribute to the pathogenesis of type 2 diabetes.