尿白蛋白排泄率对脑梗死患者发病的影响

Impact of urinary albumin excretion rate on incidence of cerebral infarction

目的探讨尿白蛋白排泄率对脑梗死患者发病的影响。方法选取2013年2月-2015年7月福建医科大学附属泉州第一医院收治的脑梗死患者450例(脑梗死组)和健康者450例(对照组),比较两组入组者的尿白蛋白排泄率,对入组者的临床资料进行多因素Logistic回归分析。结果两组尿白蛋白排泄率比较,差异有统计学意义(P<0.05),脑梗死组患者的尿白蛋白排泄率高于对照组。脑梗死组患者合并高血压、合并冠状动脉粥样硬化性心脏病、合并糖尿病、收缩压、低密度脂蛋白胆固醇、空腹血糖、尿白蛋白排泄率、吸烟及饮酒率与对照组比较,差异有统计学意义(P<0.05)。合并高血压、合并冠状动脉粥样硬化性心脏病、合并糖尿病、低密度脂蛋白胆固醇、尿白蛋白排泄率是影响脑梗死患者发病的独立危险因素(P<0.05)。结论尿白蛋白排泄率是影响脑梗死患者发病的独立危险因素,可作为预测脑梗死发生风险的重要指标之一,临床上应对高危患者进行及时干预和治疗。

Objective To investigate the impact of urinary albumin excretion rate on the incidence of cerebral infarction. Methods This study selected 450 patients with cerebral infarction in our hospital from February 2013 to July 2015 （CI group） and 450 healthy people （control group）. Urinary albumin excretion rate was compared between the two groups. Multivariate logistic regression analysis was used to analyze the clinical data. Results The urinary albumin excretion rate of the CI group was signifcantly higher than that of the control group [ （29.15 ± 4.38） vs. （14.72 ± 2.45） mg/24h, P 〈 0.05]. The rates of hypertension, coronary heart disease and diabetes, systolic blood pressure, low-density lipoprotein cholesterol, fasting blood glucose, urinary albumin excretion rate, smoking and alcohol consumption in the CI group were significantly higher than those in the control group （P 〈 0.05）. Hypertension, coronary heart disease, diabetes, low-density lipoprotein cholesterol, urinary albumin excretion rate are the independent risk factors for the onset of cerebral infarction （P 〈 0.05）. Conclusions Urinary albumin excretion is an independent risk factor for the onset of cerebral infarction, it might be used as an important index to predict the risk of cerebral infarction. Timely intervention and treatment should be carried out for high-risk patients in clinic.