脑梗死患者基质金属蛋白酶-2(MMP-2)与颈动脉粥样硬化易损性斑块的关系研究被引量：2

Relationship between Matrix Metalloproteinase-2(MMP-2) and Carotid Atherosclerotic Vulnerable Plaques in Patients with Cerebral Infarction

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摘要目的探讨基质金属蛋白酶(MMP-2)与颈动脉粥样硬化易损斑块的关系。方法对100例首次前循环型动脉粥样硬化性脑梗死恢复期患者及正常对照组80名系同期门诊体验者行颈动脉超声检查,分别测定颈动脉内膜中层厚度(IMT)、Crouse积分(CPI)、斑块总面积(CPA)。根据超声病理改变分为易损斑块组(45例)、稳定斑块组(38例)和无斑块组(50例)。依据ELISA法测定血清MMP-2、TIMP-2水平。结果易损斑块组颈动脉IMT、CPI、CPA均显著大于稳定斑块组及无斑块组(P<0.01);稳定斑块组颈动脉IMT、CPI、CPA均显著大于无斑块组(P<0.01)。易损斑块组血清MMP-2显著高于稳定斑块组及无斑块组(P<0.01),TIMP-2显著低于稳定斑块组及无斑块组(P<0.01)。易损斑块组血清MMP-2与IMT、CPI、CPA呈正相关。TIMP-2与IMT、CPI、CPA呈负相关。MMP-2/TIMP-2与IMT、CPI、CPA呈正相关。稳定斑块组血清MMP-2与IMT、CPI、CPA呈正相关;TIMP-2与IMT、CPI、CPA呈负相关;MMP-2/TIMP-2与IMT、CPI、CPA呈正相关。结论血清MMP-2、TIMP-2水平及MMP-2/TIMP-2比值与颈动脉粥样硬化易损斑块密切相关。

作者曹飞昌浩

机构地区荆州市第二人民医院宜昌市第二人民医院康复科

出处《现代诊断与治疗》 CAS 2017年第18期3341-3343,共3页 Modern Diagnosis and Treatment

关键词基质金属蛋白酶-2 易损斑块前循环型脑梗死

分类号 R743.3 [医药卫生—神经病学与精神病学]

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1吕鹤,张巍,袁云,张家勇,黄一宁.颈内动脉粥样硬化易损斑块的炎细胞、平滑肌细胞和新生血管改变[J].中华神经科杂志,2006,39(9):583-586. 被引量：7

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