摘要
随着骨缺损病患的日益增多,对骨修复材料的要求越来越高,寻求有效的方法使骨修复材料实现功能化,以改善材料与骨组织之间的相互作用及促进骨组织快速修复成了关键所在。海洋生物贻贝分泌的粘附蛋白在水环境中展现出超强粘附性能,能牢固附着于各种材料表面。受粘附蛋白启发,研究发现多巴胺(Dopamine,DA)具有与贻贝粘附蛋白类似的结构和性能,其具有超强粘附性、化学反应活性以及生物相容性;特别是其对骨细胞有优异的粘附、增殖效果,有望用于骨修复材料的表面改性。着重介绍了DA的主要性能以及其在骨修复材料表面改性方面的研究进展。
With the increase of bone defect patients,requirements of bone repair materials become higher and higher.It is important to seek effective modification methods to prepare functional bone repair materials for improving the interaction between materials and the bone tissue and promoting bone repair rapidly.Inspired by the strong adhesive proteins secreted by mussels for attachment onto various substrates in wet condition,some research indicated that dopamine（DA）possesses the similar structure and performance to mussel adhesion proteins.Because of the strong adhesion,chemical reactivity and biocompatibility of DA,it is expected to be used for bone repair materials surface modification.This paper introduces the main performance and its research progress in surface modification of bone repair materials.
出处
《材料导报》
EI
CAS
CSCD
北大核心
2017年第21期54-61,共8页
Materials Reports
关键词
多巴胺
骨修复材料
表面改性
dopamine
bone repair materials
surface modification
