氟哌酸联合雌三醇治疗绝经女性泌尿生殖道感染的疗效研究

Effect of norfloxacin combined with estriol on treatment of menopausal women with urogenital tract infections

目的探讨氟哌酸联合雌三醇治疗绝经女性泌尿生殖道感染的临床疗效及对血清炎症因子和免疫球蛋白水平影响。方法选取2015年10月-2016年12月医院妇产科门诊就诊的泌尿生殖道感染的绝经女性88例,随机分成对照组和试验组,每组44例,对照组给予氟哌酸治疗,试验组在此基础上再联合雌三醇治疗,比较两组患者治疗后血清炎症因子、免疫球蛋白以及雌激素水平和阴道pH值,评估阴道炎症状和健康评分,测量子宫内膜厚度,并比较治疗效果。结果两组血清TNF-α、IL-6、IL-8水平与治疗前比较均显著降低(P<0.01);治疗后试验组TNF-α、IL-6、IL-8水平与对照组比较均显著降低(P<0.01);两组血清IgG、IgA IgM水平与治疗前比较均明显升高(P<0.05);治疗后试验组IgG、IgA、IgM水平与对照组比较均明显升高(P<0.05);两组患者与治疗前比较阴道炎症状评分显著降低(P<0.01),阴道健康评分显著升高(P<0.01);治疗后试验组阴道炎症状评分比对照组显著降低(P<0.01),阴道健康评分显著升高(P<0.01);与治疗前比较,对照组E2水平、子宫内膜厚度以及阴道pH值无变化,试验组E2水平显著升高(P<0.01),子宫内膜厚度显著增厚(P<0.01),阴道pH值显著降低(P<0.01);与对照组比较,试验组E2水平显著升高(P<0.01),子宫内膜厚度显著增厚(P<0.01),阴道pH值显著降低(P<0.01);经4周治疗后,对照组有效率为88.64%明显低于试验组有效率95.45%,两组比较差异有统计学意义(P<0.05)。结论氟哌酸联合雌三醇治疗绝经女性泌尿生殖道感染疗效确切,具有临床应用价值。

OBJECTIVE To observe the clinical effect of norfloxacin combined with estriol on treatment of menopa-usal women with urogenital tract infections and analyze the influence on levels of serum inflammatory cytokines and immunoglobulins.METHODS A total of 88 menopausal women who were treated in outpatient department of gyne-cology and obstetrics from Oct 2015 to Dec 2016 were enrolled in the study and randomly divided into the control group and the experimental group,with 44 cases in each group.The control group was treated with norfloxacin, while the experimental group was given additional estriol on basis of norfloxacin.The levels of serum inflammatory cytokines,immunoglobulins and estrogens as well as the vaginal pH value were compared between the two groups of patients,the scores of vaginitis symptoms and health were evaluated,the endometrial thickness was measured, and the curative effect was compared.RESULTS The levels of serum TNF-α,IL-6 and IL-8 of the two groups were significantly lower after the treatment than before the treatment（P〈0.05）;the levels of TNF-α,IL-6 and IL-8 of the experimental group were significantly lower than those of the control group after the treatment（P〈0.01）. The levels of serum IgG,IgA and IgM of the two groups were significantly higher after the treatment than before the treatment（P〈0.05）,the levels of IgG,IgA and IgM of the experimental group were significantly higher than those of the control group after the treatment（P〈 0.05）.The score of vaginitis symptoms of the two groups was significantly lower after the treatment than before the treatment（P〈 0.01）,the score of vaginal health was significantly higher after the treatment than before the treatment（P〈 0.01）;the score of vaginitis symptoms of the experimental group was significantly lower than that of the control group after the treatment（P〈0.01）,and the score of vaginal health of the experimental group was significantly higher than that of the control group（P〈0.01）.There was no change in the E2 level,endometrial thickness,or vaginal pH value of the control group before and after the treatment,while the E2 level of the experimental group was significantly higher after the treatment than before the treatment（P〈0.01）,the endometrial thickness was significantly greater after the treatment than before the treatment（P〈0.01）,and the vaginal pH value was significantly less after the treatment than before the treatment（P〈0.01）.The E2 level of the experimental group was significantly higher than that of the control group（P〈0.01）,the endometrial thickness of the experimental group was significantly greater than that of the control group（P〈0.01）,and the vaginal pH value of the experimental group was significantly less than that of the control group（P〈0.01）.The effective rate of the control group was 88.64% after the treatment for 4 weeks,significantly lower than 95.45% of the experimental group（P〈0.05）.CONCLUSION Norfloxacin combined with estriol can achieve exact effect on treatment of the menopausal women with urogenital tract infec-tions,and it has clinical application value.