雷公藤多苷对寻常性银屑病患者血清中白细胞介素-6、17及23水平的影响

Effect of Tripterygium wilfordii on serum levels of IL-6, IL-17 and IL-23 in patients with psoriasis vulgaris

目的:观察雷公藤多苷治疗寻常性银屑病的疗效,并检测其对患者血清中白细胞介素(IL)-6、IL-17及IL-23水平的影响,探讨雷公藤多苷治疗寻常性银屑病的作用机制。方法:采用酶联免疫吸附试验(ELISA)法检测40例寻常性银屑病患者经雷公藤多苷治疗前后血清中IL-6、IL-17及IL-23水平变化。结果:雷公藤多苷治疗寻常性银屑病8周后银屑病皮损面积及严重度指数(PASI)评分显著下降(P<0.01)。患者血清中IL-6、IL-17及IL-23水平治疗前分别为(184.16±26.19)ng/L、(7.43±2.02)ng/L和(1622.44±254.56)ng/L,治疗后分别为(136.03±16.19)ng/L、(3.07±0.67)ng/L和(824.72±141.54)ng/L,治疗前后比较,差异有统计学意义(P均<0.01),IL-17、IL-23与PASI评分呈正相关。结论:雷公藤多苷治疗寻常性银屑病疗效显著,可能通过调节Th17细胞降低血清中IL-6、IL-17及IL-23的水平发挥作用。

Objective： To evaluate the efficacy of Tripterygium wilfordii for psoriasis vulgaris, and its effect on serum levels of IL-6, IL-17 and IL-23. Methods： ELISA assay was used to measure serum levels of IL-6, IL-17 and IL-23 in 40 pa- tients with psoriasis vulgaris before and after Tripterygium wilfordii treatment. Thirty eight normal subjects served as controls. Results： Treatments with Tripterygium wilfordii for 8 weeks lowered the PASI scores significantly（P〈0.01）. In addition, treat- ments with Tripterygium wilfordii also markedly reduced serum levels of IL-6, IL-17 and IL-23（IL-6：184.16±26.19 ng/L vs. 136.03±16.19 ng/L; IL-17：7.43±2.02 ng/L vs. 3.07±0.67 ng/L; IL-23：1622.44±254.56 ng/L vs. 824.72±141.54. P〈0.01 for all）. Both IL-17 and IL-23 levels positively correlated with PASI scores. Conclusions： Tripterygium wilfordii is effective for psoriasis vulgaris, possibly by regulating Thl7 cells, leading to reductions in serum IL-6, IL-17 and IL-23.