牙龈卟啉单胞菌调控细胞自噬的分子机制研究进展

Research advances on the molecular mechanism of autophagy regulated by Porphyromonas gingivalis

细胞自噬是细胞内一种保守的降解代谢途径,是宿主防御细菌感染的关键步骤。牙龈卟啉单胞菌(P.gingivalis)作为一种牙周致病菌,能够利用其引发的细胞自噬实现其在宿主细胞内的生存和增殖,从而逃避宿主的免疫监视。本文就P.gingivalis内化并调控各种宿主细胞发生自噬的分子机制作一综述,从而深入探讨P.gingivalis的致病作用,并拓展P.gingivalis与全身疾病关系的研究思路。

Autophagy is an intracellular conservative degradation pathway. This event has been considered as a key step in host defense against bacterial infection. However, Porphyromonas gingivalis, as one of the evidence-sufficient periodontal pathogens, can utilize self-induced autophagy to achieve persistent intracellular survival and proliferation, which enable this organism to escape from host immune surveillance. This review focuses on molecular mechanism ofP. gingivalis internalization and autophagy to illuminate its pathogenesis and to fia＇ther explore the relationship between P. gingivalis and systemic diseases.