慢性阻塞性肺疾病评估测试与肺功能相关性分析

Correlation Analysis of Chronic Obstructive Pulmonary Disease Assessment Test with Lung Function

目的:探讨慢性阻塞性肺疾病(COPD)评估测试(CAT)与第1秒用力呼气量占预计值百分比(FEV1%)及深吸气量(IC)相关性。方法:将COPD稳定期患者60例进行CAT评分和肺功能测试,对两者结果做Spearman相关分析。结果:COPD全球倡议(GOLD)分级Ⅰ、Ⅱ、Ⅲ、Ⅳ级患者分别为9、15、24、12例,CAT评分轻微、中度、严重、非常严重患者分别为13、15、19、13例。CAT评分与FEV1%及IC%总体上存在显著的相关性(r=-0.409、-0.689,均P<0.05),但GOLD分级为Ⅰ、Ⅲ、Ⅳ级的COPD患者的CAT评分与FEV1%无相关性(P>0.05),而GOLD分级为Ⅰ级的COPD患者的CAT评分与IC%无相关性(P>0.05)。对病情严重程度不同的4组COPD患者进行CAT总评分比较,差异有统计学意义(χ2=47.137,P<0.01),且任意两组间CAT总评分比较,差异均有统计学意义(χ2=13.01-75.09,均P<0.01)。结论:CAT评分与FEV1%及IC%相关性较好,可用于不同程度的COPD患者的临床检测和评估。CAT评分和FEVl、IC互为补充,能更好地反映COPD患者整体状态,对疾病的评估更全面可靠。

Objective： To investigate the correlation of chronic obstructive pulmonary disease （COPD） assessment test with FEVI~ and deep inspiratory capacity （IC）. Methods： Sixty patients with stable phase of COPD were enrolled and performed CAT score and pulmonary function test, then, Spearman correlation analysis were done according to these two results. Results： GOLD grade I ,II , III, IVpatients were 9, 15, 24, 12 cases, respectively, the CAT score in patients with mild, moderate, severe and very severe COPD were 13, 15, 19, 13 cases, respectively. CAT score existed significant correlation to FEV1% and IC% （r=-0. 409,-0. 689 ,P〈0.05）. However, the CAT score in GOLD grade I , III, IV of patients with COPD had no correlation with FEV1% （P〉0.05）, and in GOLD grade I had no correlation with IC% （P〉0.05）. Differ ence of the CAT total score was statistically significant among the four groups of COPD patients with different disease severity （χ2=47. 137, P〈0.01）, and between each two groups, differ- ences were also statistically significant （χ2 = 13. 01-75. 09, P〈0. 01）. Conclusion. The CAT score has good correlation with FEV1% and IC%. CAT score can be used for clinical testing and evaluation in different levels of patients with COPD, and may be as a supplement to FEV1 and IC, which might better reflect the overall state of patients with COPD, and be more comprehensive and reliable for evaluating the disease.