高危型人乳头瘤病毒核酸检测与液基细胞学联合诊断宫颈癌的临床意义

Significance of thinprep cytologic test and high-risk human papillom-avirus in the diagnosis of precancerous cervical diseases

目的高危型人乳头病毒核酸(HPV-DNA)检测联合液基细胞学检测(TCT)检查对宫颈癌的筛查的临床意义和诊断价值。方法对2 560例门诊就诊接受宫颈癌筛查的患者进行HPV-DNA与TCT联合检测,对HPVDNA与TCT阳性患者进行阴道镜下定位宫颈活组织检测。结果 2 560例患者中,HPV-DNA阳性患者642例,阳性率为25.07%;TCT阳性患者382例,阳性率为14.92%。病理活检阳性共202例,阳性率为28.53%。结论 HPV-DNA与TCT联合检测可以提高宫颈癌及癌前病变的检出率。

Objective To investigate the clinical significance and diagnostic value of high-risk human papillom- avirus （HPV-DNA） detection combined with liquid-based cytology （TCT） in the screening of cervical cancer. Methods HPV-DNA and TCT were detected in 2 560 outpatients with cervical cancer screening. Cervical biopsy was performed on HPV-DNA and TCT-positive patients. Results Of the 2 560 patients, there were 642 HPV-DNA positive patients with the positive rate of 25.07%, while the positive rate was 14.92% for TCT positive patients. 202 cases were confirmed positive by pathological biopsy with the positive rate of 28.53%. Conclusion Combined detection of HPV-DNA and TCT can improve the detection rate of cervical cancer and precancerous lesions.