差不嘎蒿化学成分的分离与鉴定

Isolation and identification of chemical constituents from Artemisia halodendron Turcz.ex Bess.

目的研究差不嘎蒿的化学成分。方法利用硅胶柱色谱、葡聚糖凝胶等方法对差不嘎蒿的化学成分进行分离纯化,根据其理化性质和波谱数据鉴定化合物的结构。结果从差不嘎蒿中分离得到10个化合物,分别为5-羟基-7,4'-二甲氧基二氢黄酮(5-hydroxy-7,4'-dimethoxyflavanone,1)、3,5-二羟基-7,4'-二甲氧基二氢黄酮(3,5-dihydroxy-7,4'-dimethoxyflavanone,2)、异野樱素(isosakuranetin,3)、7-羟基-5,6-二甲氧基香豆素(umckalin,4)、5,7-二羟基-3,3',4'-三甲氧基黄酮(5,7-dihydroxy-3,3',4'-trimethoxyflavone,5)、5-羟基-6,7-二甲氧基香豆素(tomentin,6)、山奈酚-4'-O-甲醚(Kaempferol-4'-O-methylether,7)、泽兰黄素(eupatrin,8)、β-谷甾醇(β-sitosterol,9)、二氢槲皮素-4'-甲醚(taxifolin-4'-methylether,10)。结论化合物4、5、7、8、10为首次从该属植物中分离得到。

Objective To study the compounds of Artemisia halodendron Turcz. ex Bess.. Methods Column chromatography of silica gel and Sephadex LH-20 were used to isolate and purify the chemical constituents from Artemisia halodendron Turcz. ex Bess.. Their structures were determined by physicochemical properties and spectral data analysis. Results Ten compounds were isolated and their structure were characterized as 5-hydroxy-7,4＇-dimethoxyflavanone（1）,3,5-dihydroxy-7,4＇-dimethoxyflavanone（2）, isosakuranetin（3）,umckalin（4）,5,7-dihydroxy-3,3＇,4＇-trimethoxyflavone（5）, tomentin（6）,Kaempferol-4＇-O-methylether（7）,eupatrin（8）,β-sitosterol（9）,and taxifolin-4＇-methyl ether（10）. Conclusions Compounds 4,5,7,8,10 are isolated from Artemisia for the first time.