益生菌治疗儿童肠易激综合征研究进展

Recent research progress of pediatric irritable bowel syndrome with probiotic therapy

肠易激综合征作为功能性胃肠疾病,影响儿童生活质量,造成儿童心理负担。肠道屏障受损、肠道炎症反应平衡失调是本病发生的可能病理生理机制。研究表明,使用益生菌治疗可有效改善肠道屏障功能,促进抗炎因子生成,使患者症状得到有效控制,达到治疗效果。然而目前益生菌的具体机制及临床应用尚处于研究阶段,本文综述肠易激综合征的致病机制和益生菌的作用机理、疗效、安全性等研究进展。

Irritable bowel syndrome is a functional gastrointestinal disorder,which can affect the quality of children＇s life and cause mental stress.Defection of the gastrointestinal barrier and imbalance of the inflammatory effect could be the physiopathological mechanism.Research shows that probiotics can improve the function of the barrier and promote the secretion of anti-inflammatory factors.Symptoms are controlled and patients get efficacy in this therapy,but the mechanism and the application of probiotics are currently still under investigation.This review concerns the pathogenic mechanism of IBS,as well as the mechanism,efficacy and safety of the probiotics.