正清风痛宁联合甲氨蝶呤在类风湿关节炎患者中辅助治疗效果及对实验室指标影响

The Effect of Zhengqingfengtongning Combined with Methotrexate on Adjuvant Therapy in Patients with Rheumatoid Arthritis and its Effect on Laboratory Indexes

目的:探讨正清风痛宁联合甲氨蝶呤在类风湿关节炎(RA)患者中辅助治疗效果及对实验室指标影响。方法:选取2014年6月-2017年5月笔者所在医院收治RA患者76例为研究对象,根据随机抽取患者就诊号法分为联合组(正清风痛宁联合甲氨蝶呤治疗)和常规组(甲氨蝶呤治疗)各38例,比较两组患者治疗前后C反应蛋白(CRP)、红细胞沉降率(ESR)、类风湿因子(RF)水平及疗效。结果:治疗前,两组患者CRP、ESR、RF水平比较均无统计学意义(P>0.05);治疗后,联合组患者CRP、ESR、RF水平均低于常规组,比较差异均有统计学意义(P<0.05)。联合组患者疗效有效率显著高于常规组,比较差异有统计学意义(97.37% vs 78.95%,P<0.05)。结论:正清风痛宁胶囊联合甲氨蝶呤在RA患者中治疗可显著降低炎症、类风湿相关实验室指标,提高临床疗效。

Objective：To investigate the effect of Zhengqingfengtongning combined with Methotrexate on adjuvant therapy in patients with rheumatoid arthritis（RA） and its effect on laboratory indexes.Method：From June 2014 to May 2017,76 RA patients in our hospital during were selected as the research object,according to randomly selected patients,were randomly divided into combined group（Zhengqingfengtongning combined with Methotrexate treatment） and the conventional group（Methotrexate treatment）,38 cases in each group,the levels of C-reactive protein（CRP）,erythrocyte sedimentation rate（ESR）,rheumatoid factor（RF） and efficacy of the two groups before and after treatment were compared.Result：Before treatment,CRP,ESR,RF levels in the two groups were not statistically significant（P〉0.05）;after treatment,the levels of CRP,ESR and RF in the combined group were lower than those in the conventional group,and the differences were statistically significant（P〈0.05）.The efficacy of the combined group was significantly higher than that of the conventional group（97.37% vs 78.95%,P〈0.05）.Conclusion：Zhengqingfengtongning combined with Methotrexate in patients with RA treatment can significantly reduce inflammation,rheumatoid related laboratory indicators,improve clinical efficacy.