实时动态血糖监测系统对2型糖尿病患者胰岛素泵强化治疗中血糖波动监测的价值

The Value of Real-time Ambulatory Blood Glucose Monitoring System in the Monitoring of Blood Glucose Fluctuation in Intensive Treatment of Insulin Pump in Patients with Type 2 Diabetes Mellitus

目的探讨实时动态血糖监测系统(CGMS)对2型糖尿病(T2DM)患者胰岛素泵强化治疗中血糖波动监测的价值。方法选择2015年1月至2016年12月我院收治的140例T2DM患者作为研究对象,随机分为研究组和对照组,每组70例,研究组采用CGMS联合胰岛素泵调整胰岛素用量进行强化治疗,对照组采用检测指尖血糖联合胰岛素泵调整胰岛素用量进行强化治疗,比较两组患者的血糖波动及血糖控制情况。结果两组患者治疗后的Hb A1c、FBG和2h BG与治疗前相比,差异具有统计学意义(P<0.05),但研究组和对照组患者治疗后的Hb A1c、FBG和2h BG相比,差异均无统计学意义(P>0.05);治疗后两组患者的血糖水平均达标,其中研究组患者的血糖达标时间显著快于对照组(P<0.05),血糖漂移度显著低于对照组(P<0.05),但血糖达标后胰岛素用量与对照组相比,差异无统计学意义(P>0.05);在治疗过程中,研究组低血糖事件检出率明显高于对照组,而且,无症状低血糖检出率也显著高于对照组,差异均具有统计学意义(P<0.05)。结论在T2DM患者强化治疗中采用CGMS检测血糖波动,能显著提高患者的低血糖检出率,有助于改善疗效。

Objective To evaluate the value of real-time dynamic glucose monitoring system （CGMS） in the monitoring of blood glucose fluctuation in patients with type 2 diabetes mellitus （T2DM） during intensive insulin pump therapy. Methods A total of 140 T2DM patients admitted in our hospital from January 2015 to December 2016 were selected as subjects. They were randomly divided into study group and control group, and each group had 70 cases. The study group were used with CGMS combined with insulin pump to adjust the amount of insulin for intensive treatment, and the control group was treated with finger blood glucose combined with insulin pump to adjust the amount of insulin for intensive treatment, blood glucose fluctuation and blood glucose control were compared in both groups. Results The levels of HbA1 c, FBG and 2hBG in the two groups were statistically significant（ P 〈 0.05 ） ,but there was no significant difference between the study group and the control group after treatment with HbAlc ,FBG and 2hBG（P 〈0.05 ）. The blood glucose level of the study groups was significantly lower than that of the control group （ P 〈 0.05 ）. The blood glucose level of the study groups was significantly higher than that of the control group （ P 〈 0.05 ）. However, the difference of blood glucose between the two groups was not statistically significant （ P 〉 0.05 ）. During the course of treatment, the detection rate of hypoglycemia in the study group was significantly higher than that in the control group, and the asymptomatic blood glucose detection rate in the study group was significantly higher than the control group （ P 〈 0.05 ）. Conclusion CGMS could be used to detect blood glucose fluctuation in T2DM patients, which can significantly improve the detection rate of hypoglycemia and improve the curative effect.