女性慢性淋巴性甲状腺炎不同阶段血总胆固醇和血红蛋白含量的变化

A Correlation Analysis of Serum Total Cholesterol and Hemoglobin with Stages of Chronic Lymphatic Thyroiditis of Female Patients

目的分析女性慢性淋巴性甲状腺炎不同阶段血总胆固醇(TC)、血红蛋白(Hb)含量并探讨其临床意义。方法将119例女性慢性淋巴性甲状腺炎患者根据促甲状腺激素(TSH)含量分为A组(一过性甲亢组)TSH<0.27 I U/ml,B组(稳定期组)TSH:0.27~4.2 IU/ml,C组(甲减组)TSH>4.2 IU/ml,另以36例健康体检者作为正常对照组。分别测定4组TSH、TC、Hb含量并进行组间比较,分析TSH与TC、Hb的相关性。结果 B组与C组TC均明显高于正常对照组(P<0.05),A组TC明显低于其他3组(P<0.05);A组与C组Hb均低于正常对照组(P<0.05);TSH与TC呈正相关(r=0.572,P<0.001),与Hb的关联无统计学意义(r=0.256,P>0.05)。结论女性慢性淋巴性甲状腺炎在其病程的不同阶段可能存在血总胆固醇和血红蛋白的改变,应注意监测。

Objective To explore the levels of serum total cholesterol （TC） and hemoglobin （Hb） in different stages of chronic lymphatic thyroiditis （CLT） in female patients and its clinical significance. Methods 119 female patients with CLT were divided into 3 groups according to serum TSH levels. Group A （patients with transient hyperthyroidism, TSH〈0.27 IU/ml） ; Group B （patients with normal serum TSH, TSH0.27-4.2 IU/ml） ： and Group C （patients with hypothyroidism, TSH〉4.2 IU/ml） . Another 36 persons, who showed normal condition after health examinations swere selected as controls. The serum levels of TSH, TC and Hb were detected and compared in the four groups. Correlations of TSH with TC and Hb were evaluated in patients with CLT. Results The serum TC level was significantly higher in Group B and Group C than in normal controls. The level of TC was notably lower in Group A than in the other 3 groups （P〈0.05） . The serum level of Hb was significantly lower in Group A and Group C than in normal controls （P〈0.05） . In patients with Hashimotor s thyroiditis, TSH was positively correlated with TC （r=0.572, P〈0.001） , but not with Hb （r=0.256, P〉0.05） . Conclusions There exists alteration of TC and Hb in different stages of chronic lymphatic thyroiditis in female patients, and timely laboratory survelliance would be necessary..