氧化三甲胺与心血管疾病研究进展

Advances in research on trimethylamine oxide with cardiovascular disease

近些年来,在控制传统危险因素的基础上中国居民心脑血管疾病的患病率与病死率仍处于上升阶段,因此探究新的心脑血管疾病影响因素尤其分子生物学标志物已成为研究热点。有研究表明肠道菌群代谢物氧化三甲胺的血浆水平升高具有促进心脑血管疾病发生与发展的作用。在高血压、冠心病、心衰、脑卒中患者中血浆氧化三甲胺水平明显升高,且对心脑血管疾病患者发生不良事件有预测价值。其主要致病机制为:促进动脉粥样硬化的发生发展,促进血栓形成。目前对于氧化三甲胺的研究主要局限于动物和特殊人群(患心脑血管疾病患者)中,未来应扩大研究对象在多中心、一般人群中研究验证。

In recent years,based on the control of traditional risk factors,the prevalence and mortality of cardiovascular diseases in Chinese residents are still in the rising stage,so the study of new cardiovascular disease factors,especially molecular biology markers has become a hot topic.Studies have shown that intestinal microbial metabolite oxidation of trimethylamine plasma levels have increased the development of the cardiovascular disease.In patients with hypertension,coronary heart disease,heart failure,stroke,plasma levels of trimethylamine were significantly increased,and cardiovascular disease in patients with adverse events have predictive value.The main pathogenesis is to promote the occurrence and development of atherosclerosis and promote thrombosis.At present,the study of trimethylamine is mainly confined to animals and special populations（patients suffering from cardiovascular and cerebrovascular diseases）.The future should be expanded in the multi-center,the general population in the study and verification.