精神分裂症血清补体C3、C4、超敏C-反应蛋白及尿酸水平变化

The levels of complement component 3, complement component 4, high sensitivity C reactive protein, and uric acid in serum of schizophrenia

目的探讨精神分裂症(schizophrenia,SZ)患者血清补体C3(complement component 3,C3)、C4(complement component 4,C4)、超敏C-反应蛋白(high sensitivity C reactive protein,hs-CRP)和尿酸(uric acid,UA)的水平变化及其临床意义。方法选择144例SZ患者为SZ组,并根据4周内有无服用抗精神病药物分为治疗组(77例)和停药组(67例),另选择同期来湘雅二医院的健康体检者147例为健康对照组。采用免疫散射比浊法、胶乳增强免疫比浊法、尿酸氧化酶法分别测定各组血清补体C3、C4、hs-CRP和UA浓度,并比较分析。结果 SZ组患者血清补体C3、C4水平低于对照组[(0.99±0.17)g/L vs.(1.03±0.17)g/L、(0.21±0.05)g/L vs.(0.23±0.05)g/L],UA水平高于对照组[(351.61±95.90)μmol/L vs.(300.28±39.57)μmol/L],差异有统计学意义(分别P<0.05,P<0.05,P<0.001)。治疗组患者血清补体C3、C4、hs-CRP和UA水平较停药组均升高[(1.04±0.19)g/L vs.(0.95±0.15)g/L、(0.22±0.06)g/L vs.(0.20±0.05)g/L、1.08(0.33,5.04)mg/L vs.0.47(0.28,1.29)mg/L、(374.54±108.33)μmol/L vs.(331.61±79.03)μmol/L],差异均有统计学意义(P<0.01)。治疗组患者血清hs-CRP和UA浓度较对照组均升高[1.08(0.33,5.04)mg/L vs.0.61(0.33,1.26)mg/L、(374.54±108.33)μmol/L vs.(300.28±39.57)μmol/L],差异有统计学意义(P<0.001)。结论 SZ患者血清C3、C4、hs-CRP和UA的水平变化对SZ临床诊断和抗精神病药物疗效评估有一定指导意义。

Objective To examine serum levels of complement component 3（C3）, complement component 4（C4）, high sensitivity C reactive protein （hs-CRP）, and uric acid （UA） in schizophrenia （SZ） patients and study their clinical significance. Methods One hundred forty-four SZ patients were recruited as SZ group. According to use of antipsychotics within four weeks, patients were divided into drug group （77 cases） and non-drug group （67 cases）. One hundred forty-seven healthy subjects from health checkup center in the second XiangYa hospital during the same period were selected as control group. The concentrations of serum C3, C4, hs-CRP, and UA from SZ patients and healthy subjects were measured using immuno-scatter turbidmetry, latex-enhanced immunoturbidimetric assay, urea oxidase method, respectively. Results The serum levels of complement C3 and C4 were lower in SZ patients than in control group [（0.99±0.17） g/L vs. （1.03±0.17） g/L,（0.21±0.05） g/L vs. （0.23±0.05） g/L], and the serum levels of UA in serum of was higher in SZ patients than in control group [（351.61±95.90）μmol/L vs. （300.28±39.57）μmol/L]. The differences had statistical significance （P〈0.05, P〈0.05, and P〈0.001, respectively）. The serum levels of C3, C4, hs-CRP, and UA were higher in drug group than in no-drug group [（1.04±0.19） g/L vs. （0.95±0.15） g/L,（0.22±0.06） g/L vs. （0.20±0.05） g/L, 1.08（0.33, 5.04） mg/L vs. 0.47（0.28, 1.29） mg/L,（374.54±108.33）μmol/L vs. （331.61±79.03） μmol/L], and the differences had statistical significance （P〈0.01）.The concentrations of serum hs-CRP and UA were higher in drug group than in control group[1.08（0.33, 5.04） mg/L vs. 0.61（0.33, 1.26） mg/L,（374.54±108.33） μmol/L vs. （300.28±39.57）μmol/L], and differences had statistical significance （P〈0.001）. Conclusion The serum levels of C3, C4, hs-CRP, and UA in SZ Patients will be of guiding significance for clinical diagnosis of SZ and efficacy evaluation of antipsychotic drugs.