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寻常性银屑病患者甲损害临床及代谢特征分析 被引量:7

Clinical and Metabolic Features of Psoriasis Vulgaris Patients with Nail Damage
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摘要 目的探讨寻常性银屑病患者甲损害特点及与临床表现、实验室指标和代谢综合征的相关性。方法选取80例寻常性银屑病患者,收集患者的人口学指标、临床及实验室检查结果,分析患者的甲损害特点,并分析甲损害与患者临床特征、实验室指标及代谢综合征的关系。结果 80例患者中,甲损害患者38例(47.50%),趾甲损害患者16例(20.00%)。与无甲损害患者相比,有甲损害的患者病程较长、病情较重,差异有统计学意义(P<0.05);有甲损害的患者头皮、上肢、躯干及下肢的皮损面积比例较高,差异有统计学意义(P<0.05);甲损害与头皮皮损面积具有相关性(P<0.05)。两组患者白细胞、中性粒细胞、淋巴细胞升高比例和代谢指标升高的患者比例差异均无统计学意义(P>0.05)。结论寻常性银屑病患者多存在甲损害,与银屑病病程长短、疾病严重程度密切相关,甲损害与头皮皮损面积相关。 Objective To investigate the clinical features of nail involvement and its relationship with clinical manifestations,laboratory findings and metabolic syndrome. Methods Eighty patients with psoriasis vulgaris were enrolled in this study. Patient's demographic data,clinical and laboratory findings were collected. The characteristics of nail involvement and its relationship with clinical manifestations,laboratory findings and metabolic syndrome were analyzed. Results Thirty-eight out of 80 patients(47.50%)had nail involvement,including 16 cases(20.00%)with toe nail damage. In comparison with patients without nail involvement,patients with nail involvement displayed more severe disease with longer disease duration(〉10 years)and larger lesion areas(P〈0.05). Neither blood cell counts(white blood cells,neutrophils,lymphocytes)nor metabolic parameters differed significantly in patients with or without nail involvement(P〉0.05). Conclusion Most patients with psoriasis vulgaris have nail involvement,which is associated with the disease duration,severity and lesion area.
出处 《中国皮肤性病学杂志》 CSCD 北大核心 2017年第12期1306-1309,共4页 The Chinese Journal of Dermatovenereology
关键词 寻常性银屑病 甲损害 皮损面积 相关性 Psoriasis vulgaris Nail involvement Lesion area Correlation
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