透明质酸凝胶与米诺环素凝胶辅助治疗慢性牙周炎的短期疗效评价

Short-term Curative Effect of Minocycline Gel and Hyaluronic Acid Gel as Adjunctive Treatment on Chronic Periodontitis

目的:对比两种不同凝胶缓释剂对慢性牙周炎患者的临床疗效。方法:将我院口腔科门诊2012年6月~2016年11月收治的105例慢性牙周炎患者按治疗方案随机分为3组,A组(n=35),B组(n=35)在机械方法治疗后分别采用透明质酸凝胶和米诺环素凝胶局部治疗,C组仅采用单纯机械方法治疗。治疗3个月后比较3组患者的慢性牙周炎病情指标变化、临床疗效及不良反应发生情况。结果:3组患者治疗前后各项指标自身对比均有显著降低,且治疗后A组与B组的结果均低于C组,另外在PLI和螺旋体构成比方面比较,B组显著低于其余两组,差异均有统计学意义(P<0.05);A组与B组临床有效率显著高于C组,差异有统计学意义(P<0.05),而A组与B组比较无差异;治疗后A组无不良反应发生,而B组在胃肠道反应方面的不良反应发生率较为显著,与A组比较有统计学差异(P<0.05)。结论:两种凝胶缓释剂在治疗慢性牙周炎的疗效相近,米诺环素凝胶可更有效的抑制菌斑及螺旋体,而透明质酸凝胶用药安全性较高且无不良反应,两种药物均可应用于临床。

Objective：To compare the curative effects of two different gels as adjunctive treatment on chronic periodontitis.Methods：One hundred and five patients with chronic periodontitis in the Department of Stomatology of our hospital from June,2012 to November,2016 were randomly divided into three groups based on therapeutic prescription：group A（n=35,hyaluronic acid gel）,group B（n=35,minocycline gel）,and group C（n=35,SRP）.After 3 months,the periodontal indexes,curative effect,and adverse drug reactions among three groups were compared.Results：Periodontal indexes in group A and B were significantly lower than that of group C（P0.05）.The PLI and percentage of spirochetes in sub-gingival plaque of group B at the 4 th week after treatment were obviously lower than those of other two groups（P0.05）.The curative rates of group A and B were obviously higher than that of C group（P0.05）.The incidence of adverse drug reactions in group A was obviously lower than that of group B（P0.05）.Conclusion：These two different gels had similar curative effect as adjunctive treatment on chronic periodontitis.