细菌对抗菌肽耐性机制研究进展

Research Progress of Bacterial Resistance to Antimicrobial Peptides

抗菌肽是机体先天免疫系统中能抵御外源性病原体的一类小分子多肽,其对细菌、真菌、寄生虫、病毒、藻类及肿瘤细胞等有着广泛的抑制作用。而研究已表明细菌能对抗菌肽产生耐药性,因此对于传统抗生素的理想替代品抗菌肽的研究与利用需要把其做为一种新型治疗剂来评估,其中需要考虑诸多因素,如解朊作用的敏感性和降低对细胞的毒副作用等。建立对其严密的参考依据能为其将在临床药物的运用奠定基础。本文对抗菌肽的特征、作用机制、细菌对其耐药性的产生以及抗菌肽运用前景做了综述。

Antimicrobial peptides（AMPs） are a class of small peptides which hold anti-extrogenous pathogen activities and exsit in innate immune system of organisms. They have been shown to have broad activities spectra against bacteria, fungus, parasites, virus, algae and cancer cells. These studies have showed that the bacteria could develop resistance to AMPs, so that it needs to be assessed as a novel therapeutics when we take them as the promising alternatives of conventional antibiotics to research and utilize them, many factors need to be considered in the process, such as their susceptibility to proteolytic degradation and reduction of toxicity to mammalian cells. It will lay the foundation of clinical drug use if strict reference basis of AMPS has been founded. The characteristics, mechanism of action, bacterial resistance to AMPs and application future of AMPs were reviewed in this paper.