MSCT灌注成像评估胃癌组织表面通透性及其与微血管密度的相关性

目的运用多层螺旋CT（MSCT）对胃癌病灶进行灌注成像检查，探讨其病灶组织的表面通透性（PS）特征，及其与微血管密度（MVD）的相关性。方法选取2014年2月至2016年9月因胃癌行手术切除并最终经术后病理证实的54例患者作为观察对象，所有观察对象于术前均接受MSCT灌注成像检查获得病灶组织的Ps值，并与术后对病灶组织标本进行病理学检查所获得的MVD作对比分析研究。结果未分化组、淋巴结转移组以及TNMⅢ-Ⅳ期组胃癌病灶组织的PS均分别明显高于相对应的分化组、淋巴结无转移组以及TNMⅠ-Ⅱ期组（P〈0．05）；未分化组、淋巴结转移组以及TNMIⅢ-Ⅳ期组胃癌病灶组织的MVD均分别明显高于相对应的分化组、淋巴结无转移组以及TNMⅠ-Ⅱ期组（P〈0．05）；胃癌病灶组织的PS与其MVD呈正相关，r值为0．672（P〈0．05）。结论MSCT灌注成像可客观无创地反映在不同临床病理特征下的胃癌病灶组织PS状态及其MVD状态，为胃癌的临床治疗提供有价值参考依据。

Objective To investigate the characteristics of permeability surface （ PS ） in gastric cancer and its correlation with microvessel density （ MVD ） using multislice spiral computed tomography （ MSCT ） perfusion imaging. Methods 54 cases of patients were selected as the research object, who underwent surgical resection in our hospital due to gastric cancer and confirmed by postoperative pathology from February 2014 to September 2016.All of the subjects were accepted MSCT perfusion imaging to obtain the PS before operation, and compared with MVD which obtained from pathological examination of postoperative lesion tissues. Results The PS in the undifferentiated group, lymph node metastasis and TNM III- IV group were significantly higher than the differentiate group, without lymph node metastasis group, TNM I - II group （ P〈0.05 ） . The MVD, lymph node metastasis and TNM III- IV in the undifferentiated group were significantly higher than the differentiate group, without lymph node metastasis group, TNM I -II group （ P〈0.05 ） . PS of gastric cancer tissue was positively correlated with MVD, R=0.672 （ P〈0.05 ） . Conclusion MSCT perfusion imaging can objectively reflect the PS and MVD status of gastric cancer lesions in different clinical pathological features, and provide valuable reference for clinical diagnosis and treatment of gastric cancer.