炎症性肠病患者生存质量及其影响因素分析

目的调查炎症性肠病患者的生存质量，分析影响生存质量的相关因素，为临床采取有针对性的干预措施提供依据。方法采用中文版SF-36量表对就诊于杭州、南京、广州的343例炎症性肠病患者进行调查，采用协方差分析比较溃疡性结肠炎和克罗恩病患者的生存质量，运用多元线性回归（进入法），分析影响生存质量的因素。结果溃疡性结肠炎和克罗恩病患者的SF．36躯体健康总分波动在23．00-74．00范围，精神健康总分波动在15．00-70．00范围，两者之间生存质量8个维度的得分差异均无统计学意义（P〉0．05），赶症性肠病患者在疾病活动期8个维度的得分均显著低于疾病缓解期（P〈0．01）。影响炎症性肠病患者生存质量的因素有疾病活动指数、住院次数、病情自评、工作（学习）状态、性别（女性生存质量显著低于男性）、家庭经济。结论溃疡性结肠炎和克罗恩病患者的生存质量相似，控制疾病活动指数，采取综合干预措施，可帮助患者早日回归工作岗位，提高生存质量。

Objective To investigate the quality of life of patients with inflammatory bowel diseases and to analyze the factors influencing the quality of life so as to provide clinicians information on effective intervention measures. Methods The Short Form-36 questionnaire was used on 343 patients from Hangzhou, Nanjing and Guangzhou, and the quality of life between patients with ulcerative colitis and Crohn＇s disease was compared using analysis of covariance （ ANCOVA ） . The influencing factors on quality of life were explored using multiple linear regression analysis. Results The physical health component score and the mental health component score of Short Form-36 in patients with ulcerative colitis and Crohn＇s disease ranged from 23.00-74.00 and 15.00-70.00 respectively. There was no significant difference in the quality of life between patients with ulcerative colitis and Crohn＇s disease for all eight dimensions of Short Form-36 （ P〉0.05 ） . Inflammatory bowel disease patients with active disease had significantly lower scores for all eight dimensions compared to those in remission （ P〈0.01 ） . Regression analysis showed that the factors influencing quality of life were mainly disease activity index, number of hospitalizations, self-evaluation of disease, working （ studying ） status, gender and economic situation. Conclusions The quality of life for patients with ulcerative colitis and Crohn＇s disease is similar. Controlling disease activity index and strengthening comprehensive interventions can improve quality of life for these patients.