长效抗菌材料预防继发性尿路感染效果的系统评价

Efficacy of long-acting antibacterial material in the prevention of secondary urinary infection: a systematic review

目的系统评价长效抗菌材料预防继发性尿路感染的效果。方法计算机检索Pub Med、The Cochrane Library、CNKI、CBM、Wan Fang Data和VIP数据库,搜集有关长效抗菌材料预防继发性尿路感染效果的随机对照试验(RCT),检索时限均从建库至2016年11月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果共纳入16个RCT。Meta分析结果显示:与常规护理相比,长效抗菌材料能降低尿路感染发生率[Peto OR=0.17,95%CI(0.13,0.23),P<0.000 01]和尿路细菌阳性率[Peto OR=0.15,95%CI(0.08,0.27),P<0.000 01]。结论当前证据表明,长效抗菌材料能够降低继发性尿路感染。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

Objective To systematically review the efficacy of long-acting antibacterial material in the prevention of secondary urinary infection. Methods PubMed, The Cochrane Library, CNKI, CBM, WanFang Data and VIP databases were electronically searched to collect randomized controlled trials （RCTs） on the efficacy of long-acting antibacterial material in the prevention of secondary urinary infection from inception to November, 2016. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using RevMan 5.3 software. Results A total of 16 RCTs were included. The results of meta-analysis showed that： the long-acting antibacterial material group was superior to the general intervention group in morbidity of secondary urinary infection （Peto OR=0.17, 95%CI 0.13 to 0.23, P〈0.000 01）, and bacterial positive rate of secondary urinary infection （Peto OR=0.15, 95%CI 0.08 to 0.27, P〈0.000 01）. Conclusion Current evidence shows that long-acting antibacterial material can effectively reduce the infection rates of secondary urinary infection. Due to limited quality and quantity of the included studies, more high quality studies are needed to verify the above conclusion.