抗生素合理干预对血流感染患者的预后研究

Impact of antimicrobial stewardship team intervention in patients with bloodstream infections

目的 :探讨抗生素干预对血流感染患者的预后影响。方法:收集本院血流感染患者及其临床资料,依据是否抗生素干预将其分成对照组和干预组,并分析对血流感染患者的临床预后。结果:共纳入201例血流感染患者,对照组104例,干预组97例。对照组和干预组在经验用药比例无统计学差异(96.2% vs 92.8%,P=0.294),对照组恰当使用抗生素比例低于干预组(68.3% vs 81.4%,P=0.032)。干预组住院时间显著少于对照组[(18.9±16.5)vs(20.6±14.7),P=0.027],干预组30 d死亡率低于对照组(6.2% vs 14.4%,P=0.056)。结论:抗生素干预能够改善患者预后,降低住院时间和死亡率。

Objective： To assess the impact of antimicrobial stewardship team（AST） intervention on clinical outcomes in patients with bloodstream infections（BSIs）. Methods： Patients with bloodstream infections were enrolled in our hospital, of them were divided into control group and intervention group according to antimicrobial stewardship team（AST） intervention. Clinical outcomes were assessed in patients with bloodstream infections. Results： A total of 201 patients with bloodstream infections were included in the final analysis： 104 patients in the control group and 97 patients in the intervention group. Both groups did not differ in the proportion of empiric antimicrobial usage. The proportion of appropriate antimicrobial usage in the control group was lower in the intervention group（68.3% vs 81.4%, P =0.032）.Compared to the control group, intervention group had decreased length of stay [（18.9±16.5） vs（20.6±14.7）, P =0.027]and mortality（6.2% vs 14.4%, P =0.056）.Conclusion： Antimicrobial stewardship programs may improve significantly antimicrobial usage with decreasing hospital length of stay and mortality.