卡维地洛对高血压的作用和对血脂、血糖和肾功能的影响

Effect of carvedilol on blood pressure, blood glucose and renal function of patients with hypertension

目的 :评价卡维地洛对高血压的作用和对血脂、血糖、肾功能的影响。方法:比较81例伴血脂、血糖代谢紊乱或肾功能不全危险因素的原发性高血压患者(危险组)和77例无危险因素的原发性高血压患者(非危险组)服用卡维地洛治疗。结果:卡维地洛治疗后两组患者的收缩压、舒张压和心率均明显下降,组间比较无统计学意义(P>0.05)。治疗前后,危险组空腹血糖和血肌酐分别为(6.55±3.10)vs(5.22±2.73)mmol·L^(-1)(P<0.01);(123.6±64.1)vs(100.6±79.1)μmol·L^(-1)(P<0.05),总胆固醇、甘油三酯和低密度脂蛋白胆固醇分别为(5.40±1.14)vs(5.09±1.01);(2.57±0.87)vs(2.04±0.97);(3.41±0.86)vs(2.77±0.50)mmol·L^(-1)(P<0.01);非危险组总胆固醇为(4.79±0.69)vs(4.51±0.68)mmol·L^(-1)(P<0.01)。卡维地洛对危险组和非危险组的治疗总效率分别为97.5%、96.1%,组间差异无统计学意义。结论:卡维地洛在有效治疗高血压的同时对其伴随的血糖、血脂和肾功能均有有益的作用。

Objective：To evaluate the effect of carvedilol on hypertension and its effects on blood lipids,blood glucose and renalfunction.Methods：Eighty-one essential hypertension patients with blood lipid and glucose metabolic disorder or risk factors of renalfunction insufficiency （risk group） and 77 essential hypertension patients without risk factors （non-risk group） took carvedilol for treatment.Results：The systolic blood pressure,diastolic blood pressure and heart rate of the two groups decreased significantly after treatment withcarvedilol,and there was no significant difference between the two groups （P〉0.05）.The fasting blood glucose and blood creatinine inthe risk group were （6.55±3.10） vs （5.22±2.73） mmol·L-1 （P〈0.01） and （123.6±64.1） vs （100.6±79.1） μmol·L-1 （P〈0.05） before and aftertreatment,and the total cholesterol,triglyceride and low density lipoprotein cholesterol were （5.40 ＋ 1.14） vs （5.09±1.01）,（2.57±0.87） vs（2.04±0.97） and （3.41±0.86） vs （2.77±0.50） mmol·L-1 （P〈0.01）.For the non-risk group,the total cholesterol was （4.79±0.69） vs （4.51±0.68）mmol·L-1 （P〈0.01）.The total effective rates of carvedilol in the risk group and the non-risk group were 97.5% and 96.1%,respectively.There was no significant difference between the two groups.Conclusion：Carvedilol has beneficial effects on the blood glucose,blood lipidand renal function of hypertensive patients.