1例获得性血友病A病例报告并文献复习

A case report and literature review of acquired hemophilia A

目的 :通过分享1例获得性血友病A(AHA)病例并复习相关文献,提高该病诊断及治疗水平。方法:结合1例十二指肠腺癌诱发获得性血友病A患者临床诊治过程及相关文献报道,对该病病因、临床表现、诊断及治疗方案进行讨论。结果:通过输注人凝血因子Ⅷ及凝血酶原复合物止血,甲泼尼龙琥珀酸钠、环磷酰胺、利妥昔单抗免疫抑制治疗,患者出院时出血停止,凝血功能基本恢复正常。结论:AHA病情凶险,及时诊断并采取综合及个体化治疗措施是决定预后的关键。

Objective：To improve the diagnosis and treatment of acquired hemophilia A by sharing one case and reviewing related literatures.Methods：By reviewing and analyzing the clinical treatment and related literature of one acquired hemophilia A （AHA） induced by duodenal adenocarcinoma,the etiology,clinical manifestations,diagnosis and treatment of the disease were discussed.Results：The patient was treated with human FⅧ and prothrombin complex for arresting the acute bleeding,and methylprednisolone,cyclophosphamide and rituximab were used to suppress immune system.When the patient was discharged,the bleeding was stopped and blood coagulation function returned to normal.Conclusion：AHA is a severe disease,therefore prompt diagnosis,individualized treatment and comprehensive measurements are the key to determine the prognosis.