喹喏酮类化合物的结构修饰及其抑菌活性研究

Study on the Structure Modification and Antibacterial Activity of Quinolone Compounds

论文以2,3,4,5-四氟苯甲酰氯为原料,在三乙胺的催化下与N,N-二甲氨基丙烯酸乙酯缩合,再分别与苄胺、苯胺、对氯苯胺、异丙胺置换、环合,构建了喹诺酮类化合物骨架,并对这一骨架进行了结构修饰,得到了一系列喹诺酮类衍生物。对这些化合物进行了抑菌活性的研究,结果表明,化合物3~8都有较好的抑菌活性,其中,化合物6 a、6 b、6 d、7、8有较强的抑菌活性。

In this paper, 2,3,4,5-Tetrafluorobenzoyl chloride was used as raw material, condensation with ethyl N,N-dimethylaminoacrylateunder the catalysis of triethylamine, then with benzylamine, aniline p-chloroaniline and isopropylaminereplacement,cyclization,the skeleton of quinolones was constructed, and the skeleton structure was modified,a series of quinolones derivatives were obtained. The antibacterial activity of these compounds was studied, The results showthat, compound 3~8 has good antibacterial activity, among them, compounds 6 a, 6 b, 6 d, 7 and 8 have strong antibacterial activity.