2型糖尿病患者血清S100A14水平与冠状动脉病变的相关性研究

Association of serum S100A14 with coronary artery disease in type 2 diabetic patients

目的:探讨血清S100A14水平与2型糖尿病患者冠状动脉(冠脉)粥样硬化病变发生的相关性。方法:入选行冠脉造影检查的2型糖尿病合并冠心病患者240例(糖尿病合并冠脉病变组)和单纯2型糖尿病患者80例(单纯糖尿病组),应用ELISA法测定患者血清S100A14水平,以冠脉病变血管支数评估冠脉病变严重程度。结果:糖尿病合并冠脉病变组血清S100A14水平显著高于单纯糖尿病组[(1 566.76±443.10)pg/mL对(959.53±140.02)pg/mL,P<0.001]。240例糖尿病合并冠脉病变患者中,单支病变80例,2支病变80例,3支病变80例。随冠脉病变支数的增多,血清S100A14水平也逐渐升高(P<0.001)。Logistic回归分析显示,血清S100A14水平是2型糖尿病患者冠脉病变发生的独立危险因素(P<0.001)。受试者工作特征(ROC)曲线分析结果表明,血清S100A14>1 046.81 pg/mL时,可以预测2型糖尿病患者冠脉病变的发生(敏感度为83.2%,特异性为85.0%)。结论:血清S100A14水平升高与2型糖尿病患者冠脉病变的发生有关。

Objective： To investigate whether serum S100A14 level is related to the presence and severity of coronary artery disease （CAD） in patients with type 2 diabetes mellitus （T2DM）. Methods： We enrolled 240 patients with T2DM and CAD （DM with CAD group） and 80 patients with T2DM only （DM group） who received coronary angiography. ELISA was used to detect the serum S100A14 levels. The severity of coronary artery lesion was assessed by the number of diseased vessels. Results： Serum levels of S100A14 were significantly higher in DM with CAD group than those in DM group 1-（1 566. 76 ± 443. 10） pg/mL vs. （959. 53 ± 140. 02） pg/mL, P〈0. 001]. Among the 240 cases of DM with CAD, there were 80 cases of one-vessel disease, 80 cases of two-vessel disease and 80 cases of three-vessel disease. As the number of diseased vessels increased, the serum S100A14 level also gradually increased （P%0. 001）. Logistic regression analysis revealed that serum S100A14 level was an independent risk factor for CAD in T2DM patients （P〈 0. 001 ）. Receiver operator characteristics （ROC） curve analysis showed that serum S100A14 level 〉1 046. 81 pg/mL could predict the presence of CAD in T2MD patients （83.2% for sensitivity and 85.0 % for specificity）. Conelusion： The elevated serum S100A14 is associated with the presence and severity of CAD in T2DM patients.