中性粒细胞/淋巴细胞计数比值与青年冠状动脉病变程度的相关性研究

Correlation between the neutrophil-to-lymphocyte ratio and the severity of coronary stenosis in young patients with coronary atherosclerotic disease

目的:探讨中性粒细胞/淋巴细胞计数比值(NLR)与青年冠状动脉(冠脉)硬化性心脏病(CAD)患者冠脉狭窄程度的关系。方法:回顾性选取45岁以下行冠脉造影者115例,根据造影结果分为CAD组(n=74)和非CAD组(n=43)。按冠脉病变程度Gensini积分将青年CAD患者分为高积分组(≥30分,n=32)和低积分组(<30分,n=40)。比较CAD组与非CAD组的危险因素差异,并采用多因素logistic回归分析NLR与冠脉病变程度的相关性。结果:与非CAD组相比,CAD组男性、吸烟及高血压占比、γ-谷腺肽转氨酶(GGT)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)、高敏C反应蛋白(hs-CRP)、白细胞计数(WBC)及NLR均明显升高,差异具有统计学意义(P均<0.05)。多因素logistic回归分析显示,在校正吸烟、hs-CRP、GGT等因素后,NLR仍是青年CAD患者冠脉狭窄程度的独立危险因素(OR=2.501,95%CI:1.439~4.364)。结论:NLR可作为青年CAD患者冠脉狭窄程度的独立危险因素。

Objective： To evaluate the correlation between the neutrophil-to-lymphocyte ratio （NLR） and the severity of coronary stenosis in young patients with coronary atherosclerotic disease （CAD）. Methods.One hundred and fifteen patients under 45 years old who had undergone coronary angiography were retrospectively selected, who were divided into CAD group （n = 74） and non-CAD group （n = 43） according to the result of angiography. The patients in CAD group were divided into two groups according to their Gensini score： high score group （≥30 points, n = 32） and low score group （〈30 points, n = 40）. NLRs were calculated in all patients. The differences of CAD risk factors between the CAD group and non-CAD group were compared. Multivariate logistic regression was used to analyze the relevance between severity of coronary artery lesions and NLR. Results： Compared with non-CAD group, the sex ratio, incidence of hypertension and smoking, 7-glutamyltranspeptidase （GCT）, triacylglycerol （TG）, total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C）, uric acid （UA）, high sensitive C reactive protein （hs-CRP） level, white blood cell count （WBC） and NLR were all significantly increased in CAD group. Multivariate logistic regression analysis showed that adjusting for smoking, hs-CRP, GGT and other factors, NLR remained as an independent risk factor forthe severity of coronary stenosis in young CAD patients （OR = 2. 501,95% CI = 1. 439-4. 364, P =0. 001）. Conclusion.. NLR can be an independent predictor for the severity of coronary stenosis in young CAD patients.