黄芪四君子汤联合成分输血对肝癌患者术后免疫功能的影响

Effect of Huangqi Sijunzi Decoction(黄芪四君子汤) Combined with Blood Component Transfusion on Postoperative Immune Function in Patients with Liver Cancer

目的:探讨黄芪四君子汤联合成分输血对肝癌患者术后免疫功能的影响。方法:将110例接受肝动脉化疗栓塞术(Transcatheter arterial chemoembolization,TACE)治疗的肝癌患者随机分为两组。对照组55例,采用复方甘草酸苷注射液联合成分输血治疗;治疗组55例,采用黄芪四君子汤联合成分输血治疗。比较治疗前后两组外周血T淋巴细胞亚群指标(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)、自然杀伤细胞(NK)、临床症状的变化情况及不良反应发生情况,并对两组临床疗效进行评价。结果:两组治疗后均CD3^+、CD4^+、NK细胞均上升,中医证候积分均下降,且治疗组上述观察指标均优于对照组,差异均有统计学意义(P<0.05);治疗组总有效率为90.91%(50/55),高于对照组的75.55%(41/55),差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:黄芪四君子汤联合成分输血可有效提高肝癌患者术后免疫功能,缓解临床症状,提高临床疗效。

Objective： To investigate the effect of Huangqi Sijunzi decoction combined with blood component transfusion on postoperative immune function in patients with liver cancer. Methods： A total of 110 patients with liver cancer received transcatheter arterial chemoembolization （TACE） were randomly divided into two groups. Control group （n=55） took compound glycyrrhizin injectioncombined with blood component transfusion; treatment group （n=55） took Huangqi Sijunzi decoction combined with blood component transfusion. The peripheral blood T lymphocyte subsets indexes （T cell subset, CD3＋, CD4＋, CD8＋, CD4＋/CDS＋）, natural killer （NK） cell, changes of clinical symptoms and adverse reactions of two groups before and after treatment were compared. The clinical efficacy was evaluated in two groups. Results： Compared with pre-treatment, the CD3＋, CD4＋, NK cell increased in two groups, while TCM symptom scores decreased, and the treatment group showed better above-mentioned indexes than control group （P〈0.05）; The total effective rate of treatment group was 90.91% （50/55）, which was higher than 75.55% （41/55） of control group （P〈0.05）; There was no statistical difference in the incidence of ad- verse reactions between the two groups （P〉0.05）. Conclusion： Huangqi Sijunzi decoction combined with blood component transfusion for patients with liver cancer can effectively increase postoperative immune function, re- lieve clinical symptoms and increase clinical efficacy.