补肾壮骨汤联合西药治疗老年性骨质疏松症的疗效及安全性评价

Clinical effects and safety of Bushen Zhuanggu decoction combined with western medicine on senile osteoporosis

目的:探讨补肾壮骨汤联合西药治疗老年性骨质疏松症的临床疗效及安全性。方法:选取我院2015年4月-2017年6月收治的96例老年性骨质疏松症患者,随机分为两组,各48例。对照组予以阿法骨化醇胶囊和钙尔奇口服治疗,观察组在此基础上加用补肾壮骨汤,共治疗8周。观察两组临床疗效及治疗前后骨密度值变化,并比较两组不良反应发生情况。结果:治疗后,观察组总有效率为91.67%,明显优于对照组的72.92%(P<0.05)。两组治疗后骨密度值均较治疗前显著提高(P<0.01),且观察组提升幅度明显大于对照组(P<0.05)。两组血常规、肝肾功能均无异常,均未出现严重呕吐及腹泻等不良反应。结论:补肾壮骨汤联合西药治疗老年性骨质疏松症,疗效确切,安全可靠,值得进一步推广应用。

Objective： To explore clinical effects and safety of Bushen Zhuanggu decoction combined with western medicine on senile osteoporosis. Methods： 96 cases of senile osteoporosis treated in our hospital from April 2015 to June 2017 were selected as research subjects and divided into two groups randomly, with 48 cases in each group. The control group received alfacalcidol and caltrate, while the observation group received Bushen Zhuanggu decoction on the basis of the control group; the treatment was of 8 weeks. The clinical effect and the bone mineral density before and after treatment of two groups were observed, the adverse reaction of two groups was compared. Results： After treatment, the total effective rate in the observation group was 91.67%, which was significantly higher than 72.92% in the control group （P〈0.05）. The bone mineral density in groups after treatment were improved significantly compared with before treatment （P〈0.01）; and the improvement of that in the observation group was significantly better than the control group （P〈0.05）. The blood, liver and kidney function were normal in two groups; and there was no severe vomiting and diarrhea and other adverse reactions. Conclusion： Bushen Zhuanggu decoction combined with western medicine had an exact effect on senile osteoporosis. It was safe, reliable and could be clinically promoted.