慢性肾功能不全患者血清同型半胱氨酸与血尿酸的相关性

Correlation between Serum Homocysteine and Serum Uric Acid of Patients with Chronic Renal Insufficiency

目的:探讨慢性肾功能不全患者血清同型半胱氨酸(Hcy)与血尿酸(UA)的相关性。方法:65例慢性肾功能不全患者作为观察组,同期健康体检者50例作为对照组,观察组患者于入院时,对照组于体检当日抽取清晨空腹静脉血,采用全自动生化仪检测血清UA含量,循环酶法检测血清Hcy含量,观察2组受检者血清UA和Hcy水平变化;采用Pearson分析法分析慢性肾功能不全患者血清UA水平与Hcy含量的相关性。结果:观察组患者血清UA和Hcy水平明显高于对照组,差异有统计学意义(P<0.05);Pearson分析结果显示,慢性肾功能不全患者的血清UA与Hcy含量呈正相关(r=0.467),差异有统计学意义(P<0.05)。结论:慢性肾功能不全患者血清UA和Hcy含量呈正相关。

Objective： To investigate the correlation between serum homocysteine（ Hcy） and serum uric acid（ UA） of patients with chronic renal insufficiency. Methods： In our hospital,65 patients with chronic renal insufficiency were used as observation group,at the same time 50 healthy people were selected as control group. At the time of admission of observation group,fasting venous blood of control group was extracted on the morning of physical examination by automatic biochemical analyzer detecting the content of serum UA and enzymatic cycling assay testing the content of serum Hcy,and changes of serum UA and the level of Hcy in 2 groups were observed. The correlation between the level of serum UA and the content of Hcy was analyzed in patients with chronic renal insufficiency by Pearson analytical method. Results： The levels of serum UA and Hcy in observation group were significantly higher than those in the control group,and the difference was statistically significant（ P〈0. 05）.The result of Pearson analysis showed that chronic renal insufficiency in patients with serum UA were positively correlated with the contents of Hcy（ r = 0. 467）,and the difference was statistically significant（ P〈0. 05）. Conclusion： Serum UA of patients with chronic renal insufficiency is positively related to the content of Hcy.