丁苯酞对急性脑梗死患者血清UCH-L1、GFAP及TNF-α水平的影响

Effect of Butylphthalide Injection on Levels of Serum UCH-L1,GFAP and TNF-α of Patients with Cerebral Infarction at Acute Stage

目的:探讨丁苯酞氯化钠注射液治疗脑梗死患者急性期对患者血清人泛素C末端水解酶(UCHL1)、胶质纤维酸性蛋白(GFAP)及肿瘤坏死因子-α(TNF-α)水平的影响。方法:选取57例急性脑梗死患者,均应用丁苯酞进行治疗,观察患者治疗前后美国国立卫生院神经功能缺损(NIHSS)评分的变化情况,同时对比患者治疗前后血清UCH-L1、GFAP及TNF-α水平变化情况。结果:与治疗前相比,治疗后NIHSS评分显著降低,差异有统计学意义(P<0.05);与治疗前相比,57例患者治疗后血清UCH-L1、GFAP及TNF-α水平均有所下降,差异有统计学意义(P<0.05);与治疗前相比,患者治疗7、14 d时Barthel指数评分显著提高(P<0.05),且治疗14 d时与治疗7 d时比较差异有统计学意义(P<0.05)。结论:丁苯酞注射液治疗脑梗死患者急性期可显著降低患者血清UCH-L1、GFAP及TNF-α水平,加速患者脑组织及神经功能的恢复对提高患者生活质量具有重要促进作用。

Objective： To investigate the effect of Butylphthalide injection on levels of serum UCHL1,GFAP and TNF-α of patients with cerebral infarction at acute stage. Methods： 57 cases of acute cerebral infarction patients were treated with butylphthalide treatment,observing the change of NIHSS score of patients before and after treatment; comparing the changes of serum UCH-L1,GFAP and TNF-levels of patients before and after treatment. Results： Compared with before treatment,NIHSS score decreased significantly after treatment,the difference was statistically significant（ P〈0. 05）;compared with before treatment,serum UCH-L1,GFAP and TNF-levels of 57 patients decreased after treatment,the differences were statistically significant（ P〈0. 05）. Compared with before treatment,the Barthel index score of patients at 7 and 14 days were significantly improved（ P〈0. 05）,and the difference between 14 d and 7 d after treatment was statistically significant（ P〈0. 05）. Conclusion：Butylphthalide injection in the treatment of patients with acute cerebral infarction can significantly reduce the serum levels of UCH-L1,GFAP and TNF-α,and accelerate the recovery of brain tissue and nerve function,which plays an important role in improving the life quality of patients.